Allele Dmel\sws^{S985D.Scer\UAS}

General Information
Symbol	Dmel\sws^{S985D.Scer\UAS}	Species	D. melanogaster
Name		FlyBase ID	FBal0215613
Feature type	allele	Associated gene	Dmel\sws

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - site directed mutagenesis
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Muhlig-Versen et al., 2005) in vitro construct - site directed mutagenesis (Muhlig-Versen et al., 2005)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	sws^Scer\UAS.cMa (Muhlig-Versen et al., 2005)
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of mutated sws coding sequence. (Muhlig-Versen et al., 2005) Amino acid replacement: S985D. (Muhlig-Versen et al., 2005)
Carried in construct	P{UAS-sws.S985D} (Muhlig-Versen et al., 2005)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In

Detailed Description
	Statement Reference Expression of sws^{S985D.Scer\UAS} in the eye under the control of Scer\GAL4^GMR.PF does not induce any esterase activity nor neuronal degeneration. (Muhlig-Versen et al., 2005)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to rescue	Scer\GAL4^elav-C155/sws^{S985D.Scer\UAS} fails to rescue sws¹ (Muhlig-Versen et al., 2005) Scer\GAL4^loco.1.3/sws^{S985D.Scer\UAS} fails to rescue sws¹ (Muhlig-Versen et al., 2005)
Comments	Expression of sws^{S985D.Scer\UAS} in either neurons or glia (under the control of either Scer\GAL4^elav-C155 or Scer\GAL4^loco.1.3) fails to rescue to wild-type NTE-like activity in sws¹ mutants. (Muhlig-Versen et al., 2005)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	sws^{S985D.Scer\UAS}
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Muhlig-Versen et al., 2005, J. Neurosci. 25(11): 2865--2873 Loss of Swiss cheese/neuropathy target esterase activity causes disruption of phosphatidylcholine homeostasis and neuronal and glial death in adult Drosophila. [FBrf0184093]

Allele Dmel\swsS985D.Scer\UAS

Allele Dmel\sws^{S985D.Scer\UAS}