FB2025_01 , released February 20, 2025
Allele: Dmel\trcS292E.UAS.L
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General Information
Symbol
Dmel\trcS292E.UAS.L
Species
D. melanogaster
Name
FlyBase ID
FBal0215626
Feature type
allele
Associated gene
Dmel\trc
Associated Insertion(s)
Carried in Construct
P{UAS-trc.L.S292E}
Key Links
Transgenic product class
missense_variant
(He et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(He et al., 2005)
Mutagen
in vitro construct
(He et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-trc.L.S292E}
Cytology
Description

Amino acid replacement: S292E.

(He et al., 2005)

UASt regulatory sequences drive expression of a mutated form of the long isoform of trc with the above amino acid substitution.

(He et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
trc
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Parkinson's disease
      modeled by Pink1RNAi.UAS.cYa
      (Wu et al., 2013)
      modeled by Pink1B9
      (Wu et al., 2013)
      DOES NOT ameliorate  Parkinson's disease
      modeled by park1, parkΔ21
      (Wu et al., 2013)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Statement
      Reference

      Scer\GAL4da.PU/trcS292E.UAS.L is a non-enhancer of visible phenotype of parkΔ21/park1

      (Wu et al., 2013)
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      Scer\GAL4da.PU/trcS292E.UAS.L is a non-suppressor of visible phenotype of parkΔ21/park1

      (Wu et al., 2013)
      Phenotype Manifest In
      NOT Enhancer of
      Statement
      Reference

      Scer\GAL4da.PU/trcS292E.UAS.L is a non-enhancer of wing phenotype of parkΔ21/park1

      (Wu et al., 2013)

      Scer\GAL4da.PU/trcS292E.UAS.L is a non-enhancer of mitochondrion phenotype of parkΔ21/park1

      (Wu et al., 2013)
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      Scer\GAL4da.PU/trcS292E.UAS.L is a non-suppressor of wing phenotype of parkΔ21/park1

      (Wu et al., 2013)

      Scer\GAL4da.PU/trcS292E.UAS.L is a non-suppressor of mitochondrion phenotype of parkΔ21/park1

      (Wu et al., 2013)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of trcS292E.Scer\UAS suppresses the defects in flight ability caused by expression of Pink1dsRNA.Scer\UAS under the control of Scer\GAL4Mhc.PW.

      The abnormal wing posture phenotype seen in flies expressing Pink1dsRNA.Scer\UAS under the control of Scer\GAL4Mhc.PW is suppressed by co-expression of trcS292E.Scer\UAS.

      The mitochondrial aggregation phenotype seen in the muscles of flies expressing Pink1dsRNA.Scer\UAS under the control of Scer\GAL4Mhc.PW is suppressed by co-expression of trcS292E.Scer\UAS.

      The mitochondrial aggregation phenotype seen in the dopaminergic neurons of Pink1B9 flies is suppressed by expression of trcS292E.Scer\UAS under the control of Scer\GAL4ple.PF.

      The loss of dopaminergic neurons in the PPL1 cluster seen in Pink1B9 flies is suppressed by expression of trcS292E.Scer\UAS under the control of Scer\GAL4ple.PF.

      Expression of trcS292E.Scer\UAS under the control of Scer\GAL4da.PU fails to rescue the abnormal wing posture and mitochondrial aggregation phenotypes seen in park1/parkΔ21 flies.

      (Wu et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      trcS292E.Scer\UAS.L
      trcS292E.Scer\UAS
      trcS292E.UAS.L
      Name Synonyms
      Secondary FlyBase IDs
        References (2)