FlyBase Allele Report: Dmel\Jra[Jbz.UAS]

Expressing Jra^Jbz.UAS under the control of Scer\GAL4^tey-5053A (together with Dicer-2, for efficient RNAI) does not provide protection against (injury-induced) Wallerian degeneration of third instar larval motoneurons.

(Hao et al., 2019)

Overexpression of Jra^Jbz.Scer\UAS in combination with Scer\GAL4^Scer\UAS.cHa driven by Scer\GAL4^Tab2-201Y does not affect axon pruning.

(Bornstein et al., 2015)

Expression of Jra^Jbz.Scer\UAS under the control of Scer\GAL4^D42 in the presence of Scer\GAL80^Cha.PK (to suppress expression in cholinergic neurons) results in a significant decrease in total dendritic length and in the number of dendritic branches in MN5 motorneurons.

(Vonhoff et al., 2013)

Expression of Jra^Jbz.Scer\UAS using Scer\GAL4^ey-OK107 does not result in any gross axonal phenotypes.

(Rallis et al., 2010)

Expression of Jra^Jbz.Scer\UAS in the RP2 motor neurons (using the Scer\GAL4^eve.RRK driver to drive expression of Scer\FLP1^Scer\UAS.cUa which then induces clones of cells expressing Scer\GAL4^Act.PU) results in a significant decrease in RP2 dendrite volume compared to controls.

(Hartwig et al., 2008)

Expression of Jra^Jbz.Scer\UAS under the control of Scer\GAL4^elav.PH in clones induced by FLP/FRT mediated recombination (to activate the Scer\GAL4^elav.PH driver) results in a decrease in the number of type 1b boutons at muscle 13 compared to wild type.

(Haussmann et al., 2008)

Expression of Jra^{bZIP.Scer\UAS} under the control of Scer\GAL4^pnr-MD237 results in a mild cleft thorax phenotype.

(Cerrato et al., 2006)

Expression of Jra^Jbz.Scer\UAS under the control of Scer\GAL4^elav-C155 results in an approximately 25% reduction in EJC amplitude (synaptic strength) and bouton number at the larval neuromuscular junction. mEJC amplitude is not significantly altered.

(Sanyal et al., 2002)

Scer\GAL4-mediated expression in the eye imaginal disc interferes with proper eye development.

(Eresh et al., 1997)

Scer\GAL4^C-765, Scer\GAL4^69B and Scer\GAL4^hs.PB-mediated expression causes defects in head and dorsal cuticle. Scer\GAL4^C-765 induces predominantly an anterior open-like phenotype and Scer\GAL4^69B and Scer\GAL4^hs.PB lead to phenotypes that progressively affect the entire dorsal cuticle. No defects in posterior structures and filzkorper are observed.

(Kockel et al., 1997)

Causes no effect on copper cell development, when expression is driven by Scer\GAL4^48Y.

(Riese et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Jra^Jbz.UAS, Scer\GAL4^elav-C155 has abnormal neuroanatomy phenotype, suppressible by puc^E69

(Sanyal et al., 2002)

Jra^Jbz.UAS, Scer\GAL4^elav-C155 has abnormal neurophysiology phenotype, suppressible by puc^E69

(Sanyal et al., 2002)

Enhancer of

Statement

Reference

Jra^Jbz.UAS, Scer\GAL4^ey-OK107 is an enhancer of abnormal neuroanatomy phenotype of Scer\GAL4^ey-OK107, bsk^GD10555

(Rallis et al., 2010)

Suppressor of

Statement

Reference

Scer\GAL4^tey-5053A/Jra^Jbz.UAS is a suppressor | partially of abnormal neuroanatomy | recessive | third instar larval stage | conditional phenotype of raw^dcp-1

(Hao et al., 2019)

Jra^Jbz.UAS, Scer\GAL4^ptc-559.1 is a suppressor | partially of abnormal cell migration | third instar larval stage phenotype of Scer\GAL4^ptc-559.1, puc^GD1515

(Zhang et al., 2019)

Scer\GAL4^elav.PU/Jra^Jbz.UAS is a suppressor | partially of abnormal neuroanatomy | maternal effect | larval stage phenotype of SkpA^GD65

(Brace et al., 2014)

NOT Suppressor of

Statement

Reference

Scer\GAL4^BG380/Jra^Jbz.UAS is a non-suppressor of abnormal neurophysiology phenotype of hiw^ND8

(Collins et al., 2006)

Other

Statement

Reference

Jra^Jbz.UAS, Scer\GAL4^tey-5053A, raw^dcp-1 has abnormal neuroanatomy | third instar larval stage phenotype

(Hao et al., 2019)

Jra^Jbz.UAS, Scer\GAL4^ey-OK107, kay^Fbz.UAS has abnormal neuroanatomy phenotype

(Rallis et al., 2010)

Jra^Jbz.UAS, Mnn1^UAS.cCa, Scer\GAL4^how-24B has lethal | pupal stage P7 phenotype

(Cerrato et al., 2006)

Phenotype Manifest In

Enhanced by

Statement

Reference

Jra^Jbz.UAS, Scer\GAL4^pnr-MD237 has adult thorax phenotype, enhanceable by Mnn1^UAS.cCa, Scer\GAL4^pnr-MD237

(Cerrato et al., 2006)

Suppressed by

Statement

Reference

Jra^Jbz.UAS, Scer\GAL4^elav-C155 has bouton phenotype, suppressible by puc^E69

(Sanyal et al., 2002)

Jra^Jbz.UAS, Scer\GAL4^elav-C155 has neuromuscular junction | larval stage phenotype, suppressible by puc^E69

(Sanyal et al., 2002)

Enhancer of

Statement

Reference

Jra^Jbz.UAS, Scer\GAL4^ey-OK107 is an enhancer of Kenyon cell phenotype of Scer\GAL4^ey-OK107, bsk^GD10555

(Rallis et al., 2010)

Jra^Jbz.UAS, Scer\GAL4^ey-OK107 is an enhancer of axon phenotype of Scer\GAL4^ey-OK107, bsk^GD10555

(Rallis et al., 2010)

Jra^Jbz.UAS, Scer\GAL4^pnr-MD237 is an enhancer of adult thorax phenotype of Mnn1^UAS.cCa, Scer\GAL4^pnr-MD237

(Cerrato et al., 2006)

Suppressor of

Statement

Reference

Scer\GAL4^tey-5053A/Jra^Jbz.UAS is a suppressor | partially of axon | third instar larval stage | conditional phenotype of raw^dcp-1

(Hao et al., 2019)

Scer\GAL4^tey-5053A/Jra^Jbz.UAS is a suppressor | partially of embryonic/larval motor neuron | third instar larval stage | conditional phenotype of raw^dcp-1

(Hao et al., 2019)

Jra^Jbz.UAS, Scer\GAL4^ptc-559.1 is a suppressor | partially of anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype of Scer\GAL4^ptc-559.1, puc^GD1515

(Zhang et al., 2019)

Scer\GAL4^elav.PU/Jra^Jbz.UAS is a suppressor | partially of NMJ bouton | maternal effect | larval stage phenotype of SkpA^GD65

(Brace et al., 2014)

Scer\GAL4^elav.PU/Jra^Jbz.UAS is a suppressor | partially of embryonic/larval neuromuscular junction | maternal effect | larval stage phenotype of SkpA^GD65

(Brace et al., 2014)

NOT Suppressor of

Statement

Reference

Scer\GAL4^BG380/Jra^Jbz.UAS is a non-suppressor of neuromuscular junction phenotype of hiw^ND8

(Collins et al., 2006)

Scer\GAL4^BG380/Jra^Jbz.UAS is a non-suppressor of bouton phenotype of hiw^ND8

(Collins et al., 2006)

Other

Statement

Reference

Jra^Jbz.UAS, Scer\GAL4^tey-5053A, raw^dcp-1 has axon | third instar larval stage phenotype

(Hao et al., 2019)

Jra^Jbz.UAS, Scer\GAL4^tey-5053A, raw^dcp-1 has embryonic/larval motor neuron | third instar larval stage phenotype

(Hao et al., 2019)

Jra^Jbz.UAS, Scer\GAL4^ey-OK107, kay^Fbz.UAS has axon phenotype

(Rallis et al., 2010)

Jra^Jbz.UAS, Scer\GAL4^ey-OK107, kay^Fbz.UAS has Kenyon cell phenotype

(Rallis et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

raw^dcp-1 homozygotes show protection against (injury-induced) Wallerian degeneration in third instar larval motor neurons, which is considerably suppressed by the expression of Jra^Jbz.UAS under the control of Scer\GAL4^tey-5053A; in these double mutants, injured axons exhibit severely decreased new growth/sprouting compared to controls.

(Hao et al., 2019)

The synaptic overgrowth phenotype (increase in bouton number) seen at the neuromuscular junction in larvae derived from homozygous SkpA^GD65 females is partially suppressed by expression of Jra^Jbz.Scer\UAS under the control of Scer\GAL4^elav.PU.

(Brace et al., 2014)

The reduction in total dendritic length and in the number of dendritic branches which is seen in MN5 motorneurons in animals expressing Jra^Jbz.Scer\UAS under the control of Scer\GAL4^D42 in the presence of Scer\GAL80^Cha.PK (to suppress expression in cholinergic neurons) is not altered if the flies are also simultaneously co-expressing both Sh^{DN.EKI.Scer\UAS} and eag^{DN.EKI.Scer\UAS}.

(Vonhoff et al., 2013)

Co-expression of kay^Fbz.Scer\UAS and Jra^Jbz.Scer\UAS results in axon degeneration phenotypes.

Co-expression of two copies of Jra^Jbz.Scer\UAS strongly enhances the axonal defects seen in Scer\GAL4^ey-OK107, bsk^GD10555 animals.

(Rallis et al., 2010)

The border follicle cell migration defects that are seen in flies co-expressing both Pvr^DN.Scer\UAS and hep^Act.Scer\UAS under the control of Scer\GAL4^slbo.2.6 are not strongly affected by the co-expression of Jra^Jbz.Scer\UAS.

(Mathieu et al., 2007)

The cleft thorax phenotype of flies that express either Mnn1^Scer\UAS.cCa or Jra^{bZIP.Scer\UAS} under the control of Scer\GAL4^pnr-MD237 is enhanced when Mnn1^Scer\UAS.cCa and Jra^{bZIP.Scer\UAS} are expressed together by Scer\GAL4^pnr-MD237. Further, flies that coexpress Mnn1^Scer\UAS.cCa and Jra^{bZIP.Scer\UAS} under the control of Scer\GAL4^how-24B are lethal at pupal stage P7, which is earlier than the pharate adult lethality of Scer\GAL4^how-24B>Mnn1^Scer\UAS.cCa flies.

(Cerrato et al., 2006)

Expression of Jra^Jbz.Scer\UAS, under the control of Scer\GAL4^BG380 does not suppress the hiw^ND8 synaptic phenotype.

(Collins et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

7217

w¹¹¹⁸; P{Jbz}1

7218

y¹ w¹¹¹⁸; P{Jbz}10

Notes on Origin

Discoverer

Comments

Protein acts as a dominant negative as the bZIP domain is able to dimerize and bind DNA without being able to stimulate transcription.

(Eresh et al., 1997)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Jbz

(Cerrato et al., 2004)

Jra^DN

(Hsu et al., 2021)

Jra^Jbz.Scer\UAS

Jra^Jbz.UAS

Jra^{bZIP.Scer\UAS}

Jra^bZIP.UAS

Name Synonyms

Secondary FlyBase IDs

FBal0060635
FBal0063160

References (27)

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