|Feature type||allele||Associated gene||Dmel\mamo|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
Transcripts expressed from this allele have alterations in 5'UTR length compared to wild-type transcripts.
|Phenotype Manifest In|
mamoSVA53 embryos derived from mamoSVA53/mamoSVA53 germline clones fertilized by wild-type sperm form normal numbers of pole cells, most of which successfully migrate into the embryonic gonads. Embryos resulting from the transplantation of mamoSVA53 pole cells into host embryos that lack pole cells develop into sterile flies. Although females transplanted with mamoSVA53 pole cells are able to lay eggs, these eggs fail to initiate cleavage division and therefore do not develop. In oocytes drived from mamoSVA53 pole cells, initiation of meiosis is not affected but the disassembly of the synaptonemal complex is retarded. Karyosomes are severely fragmented in 32% of mamoSVA53 oocytes during stages 8-10. After ovulation, meiotic divisions are severely impaired and most of the meiotic divisions are scattered. Meiotic products, such as polar-body nuclei or rossette structures, are observed in 6.9% of mamoSVA53 eggs. mamoSVA53 eggs are capable of accepting sperm, however sperm nuclei fail to decondense and remain separated from female chromosomes until at least 1 hour AEL. All host males transplanted with mamoSVA53 pole cells are sterile.
|Phenotype Manifest In|
|Complementation & Rescue Data|
|Stocks ( 0 )|
|Notes on Origin|
Selected as: a mutation which affects the expression of pole cell enhancer trap markers.
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 1 )|
|Secondary FlyBase IDs|
|References ( 1 )|