Homozygous neurons (generated via a Scer\FLP1SOP
/ MARCM method) show a complicated phenotype that combines features of both undergrowth and miniaturization.
Mutant embryos have a normal somatic muscle pattern. The number of nuclei in the segmental border muscle is normal.
Homozygotes show a dendritic tiling defect in class IV dendrite arborization (da) neurons, with 8.1 +/- 1.7% of dendritic branches crossing one another. In addition, the total number of dendrite branches is reduced to approximately 80% of wild type.
Single-cell dorsal class IV da neuron clones that are homozygous for rictorΔ2
(in a heterozygous background) show defects in dendritic tiling, with a significantly higher number of dendritic branches crossing one another compared to wild type.
The v'ada and vdaB dendrites often invade neighbouring dendritic fields in homozygous mutants, in contrast to what is seen in wild-type controls.
flies are normal in appearance.
flies raised under controlled conditions on a rich diet show a modest (approximately 10%) reduction in body weight and a modest reduction in tissue growth (wing area is reduced) compared to controls.
flies raised on nutrient-reduced food show growth that is indistinguishable from that of wild-type controls raised under the same conditions.