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General Information
Symbol
Dmel\KCNQ64B
Species
D. melanogaster
Name
FlyBase ID
FBal0215873
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Mobilisation of P{EP}KCNQEP2074 results in a deletion from +453 to +3493, encompassing exons 3-7, predicted to delete part of S1, S2-S6 transmembrane domains and a conserved CaM-binding site.
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Eggs laid by KCNQ64B homozygous mothers fail to hatch into larvae. This embryonic lethality is only associated with homozygous KCNQ64B mothers. Homozygous KCNQ64B males have normal fertility, as they produce adult progeny when mated to wild-type females. Heterozygous embryos from homozygous KCNQ64B females and wild-type males still fail to hatch, even with a copy of the wild-type gene from the male. The lack of paternal rescue indicates that the time window when KCNQ is critical lies before the zygotic expression of the gene. The nuclei of 1-2 hour old KCNQ64B mutant embryos are disorganised in comparison to wild-type. Some nuclei appear to be broken down into smaller fragments, whereas others have clustered abnormally, indicating that development of the mutant embryo is arrested before the cellularisation stage.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
KCNQ64B
Name Synonyms
Secondary FlyBase IDs
    References (1)