FB2025_01 , released February 20, 2025
Allele: Dmel\CharonEY18569
Open Close
General Information
Symbol
Dmel\CharonEY18569
Species
D. melanogaster
Name
FlyBase ID
FBal0215903
Feature type
allele
Associated gene
Dmel\Charon
Associated Insertion(s)
P{EPgy2}CharonEY18569
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Bellen, 2008.5.7)
Progenitor genotype
Associated Insertion(s)
P{EPgy2}CharonEY18569
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{EPgy2}
Regulatory region(s)
UASp
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  amyotrophic lateral sclerosis type 8
      modeled by Vap33P58S.UAS.Tag:FLAG
      (Sanhueza et al., 2015)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      CharonEY18569/Df(2L)Exel7006 flies exhibit significantly reduced susceptibility to infection with L. monocytogenes, P. rettgeri and B. subtilis; this enhanced resistance to L. monocytogenes is accompanied with a reduced bacterial load both 24 and 48 hrs post-infection, as compared to wild type.

      CharonEY18569/Df(2L)Exel7006 and CharonEY18569/+ flies exhibit significantly increased survival in response to systemic infection with L. monocytogenes, P. rettgeri and B. subtilis, as compared to wild type.

      (Morris et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      CharonEY18569/Charon[+] is rescued by CharonUAS.cMa/Scer\GAL4c564

      (Morris et al., 2016)
      Comments

      Expression of CharonScer\UAS.cMa under the control of Scer\GAL4c564 suppresses the increased survival seen in CharonEY18569/+ flies in response to L. monocytogenes, P. rettgeri and B. subtilis infection.

      (Morris et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      CG5118EY18569
      (Bellen, 2008.5.7)
      CharonEY18569
      pickleP[EPgy2]EY18569
      (Morris et al., 2016)
      pickleey
      (Morris et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)