Allele Dmel\Dys^GS12472

General Information
Symbol	Dmel\Dys^GS12472	Species	D. melanogaster
Name		FlyBase ID	FBal0216505
Feature type	allele	Associated gene	Dmel\Dys

Allele class
Mutagen
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Caused by insertion	P{GSV1}Dys^GS12472 (van der Plas et al., 2006, Pilgram et al., 2011)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In

Detailed Description
	Statement Reference
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference Scer\GAL4^G14/Dys^GS12472 is a suppressor \| partially of neurophysiology defective \| dominant phenotype of cv-c¹ (Pilgram et al., 2011)
Phenotype Manifest In
Suppressor of
Statement Reference Scer\GAL4^G14/Dys^GS12472 is a suppressor \| partially of neuromuscular junction phenotype of cv-c¹ (Pilgram et al., 2011)
Additional Comments
Genetic Interactions
Statement Reference The increased quantal content (QC) measured at the neuromuscular junction of cv-c[1]/+ mutants is reduced as a result of expression of Dys[GS12472] under the control of Scer\GAL4[G14]. (Pilgram et al., 2011)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescues	Scer\GAL4^G14/Dys^GS12472 rescues Dys^E6 (van der Plas et al., 2006)
Fails to rescue	Scer\GAL4^Rapgap1-OK6/Dys^GS12472 fails to rescue Dys^E6 (van der Plas et al., 2006)
Comments	Postsynaptic expression of Dys^GS12472 under the control of Scer\GAL4^G14 in a heterozygous Dys^E6/+ background rescues quantal content to wild-type levels. Expression pre-synaptically (under the control of Scer\GAL4^OK6) does not rescue quantal content. (van der Plas et al., 2006)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	det^GS12472 Dys^GS12472 GS12472 (van der Plas et al., 2006)
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Pilgram et al., 2011, J. Neurosci. 31(2): 492--500 The RhoGAP crossveinless-c Interacts with Dystrophin and Is Required for Synaptic Homeostasis at the Drosophila Neuromuscular Junction. [FBrf0212767] van der Plas et al., 2006, J. Neurosci. 26(1): 333--344 Dystrophin is required for appropriate retrograde control of neurotransmitter release at the Drosophila neuromuscular junction. [FBrf0191057]

Allele Dmel\DysGS12472

Allele Dmel\Dys^GS12472