Allele Dmel\Dcr-1^Scer\UAS.cDa

General Information
Symbol	Dmel\Dcr-1^Scer\UAS.cDa	Species	D. melanogaster
Name	Saccharomyces cerevisiae UAS construct a of Dietzl	FlyBase ID	FBal0216507
Feature type	allele	Associated gene	Dmel\Dcr-1

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Dietzl et al., 2007)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of Dcr-1. (Dietzl et al., 2007)
Carried in construct	P{UAS-Dcr-1.D} (Dietzl et al., 2007, Berdnik et al., 2008, Berdnik et al., 2008, Gehrke et al., 2010, Lee et al., 2011, Herranz et al., 2010)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In

Detailed Description
	Statement Reference Co-expression of Dcr-1[Scer\UAS.cDa] restores cell and tissue size in wings expressing Scer\GAL4[en-e16E]>Dcr-1[GD11429]. (Herranz et al., 2010)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference Dcr-1^Scer\UAS.cDa, Scer\GAL4^ple.PF is a suppressor of neuroanatomy defective phenotype of Lrrk^{I1915T.Scer\UAS}, Scer\GAL4^ple.PF (Gehrke et al., 2010)
Phenotype Manifest In
Suppressor of
Statement Reference Dcr-1^Scer\UAS.cDa, Scer\GAL4^ple.PF is a suppressor of dopaminergic neuron phenotype of Lrrk^{I1915T.Scer\UAS}, Scer\GAL4^ple.PF (Gehrke et al., 2010)
Additional Comments
Genetic Interactions
Statement Reference In flies expressing Lrrk[I1915T.Scer\UAS] driven by Scer\GAL4[ple.PF], Dcr-1[Scer\UAS.cDa]-overexpression suppresses the neuronal toxicity of Lrrk[I1915T.Scer\UAS]. (Gehrke et al., 2010)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescues	Dcr-1^Scer\UAS.cDa/Scer\GAL4^GH146 rescues Dcr-1^LL06357 (Berdnik et al., 2008)
Comments	Expression of Dcr-1[Scer\UAS.cDa] under the control of Scer\GAL4[GH146] rescues the projection neuron defects seen in Dcr-1[LL06357] projection neuron neuroblast clones (MARCM clones labelled using Scer\GAL4[GH146]). Expression of Dcr-1[Scer\UAS.cDa] under the control of Scer\GAL4[GH146] rescues the projection neuron defects (both the dendritic and axon defects) seen in single cell Dcr-1[LL06357] DL1 projection neuron clones. (Berdnik et al., 2008)
Stocks ( 1 )
Bloomington	36510 y¹ w^*; P{UAS-Dcr-1.D}3
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Dcr-1^Scer\UAS.cDa
Name Synonym	Saccharomyces cerevisiae UAS construct a of Dietzl
Secondary FlyBase IDs

References ( 6 )
Research paper	Lee et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(33): 13794--13799 Serotonin-mushroom body circuit modulating the formation of anesthesia-resistant memory in Drosophila. [FBrf0214737] Gehrke et al., 2010, Nature 466(7306): 637--641 Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression. [FBrf0211387] Herranz et al., 2010, EMBO J. 29(10): 1688--1698 The miRNA machinery targets Mei-P26 and regulates Myc protein levels in the Drosophila wing. [FBrf0210816] Berdnik et al., 2008, Curr. Biol. 18(22): 1754--1759 MicroRNA Processing Pathway Regulates Olfactory Neuron Morphogenesis. [FBrf0206335] Dietzl et al., 2007, Nature 448(7150): 151--156 A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila. [FBrf0200691]
Supplementary material	Berdnik et al., 2008, Curr. Biol. 18(22): Supplemental Data. [FBrf0210620]

Allele Dmel\Dcr-1Scer\UAS.cDa

Allele Dmel\Dcr-1^Scer\UAS.cDa