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General Information
Symbol
Dmel\rumiΔ26
Species
D. melanogaster
Name
FlyBase ID
FBal0216685
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference
Imprecise excision of the P{EPgy2}CG7023EY00249 insertion, resulting in a deletion that removes most of the rumi open reading frame.
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
1-day old homozygous adults raised at 18[o]C (in ambient light) show a 100% penetrant rhabdomere attachment phenotype, with 2 or more rhabdomeres in each ommatidium being attached to each other. The severity of the phenotype is similar in 15 and 40 day old mutant flies. At 65% pupal development, the area of the inter-rhabdomeral space (IRS) in mutant ommatidia is 59% smaller than in controls, while in adults the IRS of mutant ommatidia appears similar to that of controls.
At 25 [o]C, some homozygous rumiΔ26 mutant animals reach adulthood but display very severe loss of bristles on the thorax and shortening of the legs. These flies die on the food after eclosion or trapped in the pupal case during eclosion, presumably owing to leg defects. As the temperature is decreased to room temperature (21-23 [o]C), approximately three quarter of the rumiΔ26 mutants exhibit an intermediate loss of microchaetae. At room temperature, the legs are not short, but subtle leg joint defects are commonly observed. When raised at 18 [o]C, most homozygous rumiΔ26 animals show loss of small patches of microchaetae in anterior parts of the notum and slight increase in the density of microchaetae. No shortening of the legs is observed at 18 [o]C, although most animals show minor defects in leg joints. Homozygous rumiΔ26 mutant animals fail to reach the pharate adult stage when cultured at temperatures above 25 [o]C.
rumiΔ26 mitotic clones raised at 30[o]C exhibit the loss of thoracic sensory bristles and margin loss and vein expansion in the wing.
rumiΔ26 embryos lacking both maternal and zygotic rumi function raised at 28oC have a neurogenic phenotype.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference
rumiΔ26 has lethal | heat sensitive phenotype, suppressible by Ngt-16-20
rumiΔ26 has visible | recessive phenotype, suppressible by Ngt-16-35
rumiΔ26 has lethal | heat sensitive phenotype, suppressible by Ngt-16-35
rumiΔ26 has visible | recessive phenotype, suppressible by Ngt-12.14.15
rumiΔ26 has lethal | heat sensitive phenotype, suppressible by Ngt-12.14.15
rumiΔ26 has visible | recessive phenotype, suppressible by Ngt-12
rumiΔ26 has lethal | heat sensitive phenotype, suppressible by Ngt-12
rumiΔ26 has visible | recessive phenotype, suppressible by Ngt-10.13-15
rumiΔ26 has lethal | heat sensitive phenotype, suppressible by Ngt-10.13-15
rumiΔ26 has lethal | heat sensitive phenotype, suppressible by Ngt-10.12.14.15
rumiΔ26 has lethal | heat sensitive phenotype, suppressible by Ngt-10-15
rumiΔ26 has visible | recessive phenotype, suppressible by Ngt-4.5
rumiΔ26 has lethal | heat sensitive phenotype, suppressible by Ngt-4.5
rumiΔ26 has visible | recessive phenotype, suppressible by Ngt-24-35
rumiΔ26 has lethal | heat sensitive phenotype, suppressible by Ngt-24-35
rumiΔ26 has visible | recessive phenotype, suppressible by Ngt-16-20
NOT suppressed by
Statement
Reference
rumiΔ26 has lethal | heat sensitive phenotype, non-suppressible by Ngt-10-20
rumiΔ26 has lethal | heat sensitive phenotype, non-suppressible by Ngt-10-35
rumiΔ26 has lethal | heat sensitive phenotype, non-suppressible by Ngt-4-35
Suppressor of
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference
rumiΔ26 has rhabdomere phenotype, enhanceable by eys734/eys[+]
rumiΔ26 has rhabdomere phenotype, enhanceable by Hsc70-3G0102/Hsc70-3[+]
Suppressed by
Statement
Reference
rumiΔ26 has notal microchaeta phenotype, suppressible by Ngt-12
rumiΔ26 has leg phenotype, suppressible | partially by Ngt-4-35
rumiΔ26 has joint phenotype, suppressible | partially by Ngt-4-35
NOT suppressed by
Statement
Reference
Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference
eys734/+ strongly enhances the rhabdomere attachment phenotype of rumiΔ26 homozygotes raised at 18[o]C: multiple rhabdomeres collapse into one another in each ommatidium and there is a dramatic decrease in the size of the inter-rhabdomeral space (although small pockets of it are still present in each ommatidium). Hsc70-3G0102/+ enhances the rhabdomere attachment phenotype of rumiΔ26 homozygotes raised at 18[o]C (the average number of separate rhabdomeres is reduced). Hsc70-3G0102/+ ; rumiΔ26/+ double heterozygotes raised at 18[o]C do not show a rhabdomere attachment phenotype.
Homozygous rumiΔ26 mutant animals also carrying Ngt-10-20 fail to reach the pharate adult stage when cultured at temperatures above 25 [o]C. Homozygous rumiΔ26 mutant animals also carrying Ngt-10-35 fail to reach the pharate adult stage when cultured at temperatures above 25 [o]C. Homozygous rumiΔ26 mutant animals also carrying Ngt-4-35 fail to reach the pharate adult stage when cultured at temperatures above 25 [o]C. Mutants cultured at room temperature (21-23 [o]C), similarly to rumiΔ26 single mutants, commonly exhibit mild defects in leg joints. At 18 [o]C, the mutants show a mild loss of microchaetae and normal legs. rumiΔ26 fully suppresses the NScer\UAS.ΔLNR.T:Ecol\lexA wing imaginal disc phenotypes.
Xenogenetic Interactions
Statement
Reference
Overexpression of Hsap\POGLUT1Scer\UAS.T:Zzzz\FLAG suppresses the sensory organ and wing phenotypes of rumiΔ26 mitotic clones raised at 30[o]C. Overexpression of Hsap\KDELC1Scer\UAS.T:Zzzz\FLAG or Hsap\KDELC2Scer\UAS.T:Zzzz\FLAG fails to suppress the sensory organ and wing phenotypes of rumiΔ26 mitotic clones raised at 30[o]C.
Complementation and Rescue Data
Comments
rumigt.T:Zzzz\FLAG rescues the rhabdomere attachment phenotype seen in rumiΔ26 flies raised at 18[o]C.
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (5)