FB2025_01 , released February 20, 2025
Allele: Dmel\zldunspecified
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General Information
Symbol
Dmel\zldunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0216889
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    The nuclei of mutant early embryos are abnormally shaped and increased in size compared to controls. The nuclei fail to become properly aligned in a single layer below the cortical membrane of the preblastoderm embryo. Deep folds are seen in mutant blastoderm embryos, which remain in pregastrulating embryos. The region adjacent to the folds is marked by enlarged nuclei in the embryos. Giant cells containing multiple dividing nuclei are occasionally seen, indicating incomplete cytokinesis.

    The synchronous mitotic wave normally seen in blastoderm embryos is abnormal in hemizygous embryos. Defects range from abnormal starting points of the waves and include asynchronous divisions as shown by a "salt and pepper" distribution of nuclei that are in different mitotic stages. DNA replication is also asynchronous.

    External Data
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    Phenotypic Class
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    Additional Comments
    Genetic Interactions
    Statement
    Reference
    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (2)
    Reported As
    Symbol Synonym
    vflunspecified
    zldunspecified
    Name Synonyms
    Secondary FlyBase IDs
      References (2)