FB2025_01 , released February 20, 2025
Allele: Dmel\Nup50KG09557
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General Information
Symbol
Dmel\Nup50KG09557
Species
D. melanogaster
Name
FlyBase ID
FBal0217332
Feature type
allele
Associated gene
Dmel\Nup50
Associated Insertion(s)
P{SUPor-P}Nup50KG09557
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{SUPor-P}Nup50KG09557
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    P{SUPor-P}
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 1 )
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Nup50KG09557 moderately lengthens the lifespan of flies with an 11% increase in survival compared with wild-type.

        (Zhan et al., 2013)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhancer of
        Statement
        Reference

        Nup50KG09557 is an enhancer of visible phenotype of Scer\GAL4GMR.PU, Zzzz\GGGGCC58.UAS.EGFP

        (Freibaum et al., 2015)
        Suppressor of
        Statement
        Reference

        Nup50KG09557 is a suppressor of short lived phenotype of Hsap\TARDBPUAS.cHa, Scer\GAL4Toll-6-D42

        (Zhan et al., 2013)
        Phenotype Manifest In
        Enhancer of
        Statement
        Reference

        Nup50KG09557 is an enhancer of eye phenotype of Scer\GAL4GMR.PU, Zzzz\GGGGCC58.UAS.EGFP

        (Freibaum et al., 2015)
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference

        The presence of the Nup50KG09557 mutation enhances the rough eye phenotype seen in flies expressing Zzzz\GGGGCC58.Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4GMR.PU.

        (Freibaum et al., 2015)

        Nup50KG09557 seems to preferentially increase maximum lifespan of Scer\GAL4D42>Hsap\TARDBPScer\UAS.cHa flies.

        (Zhan et al., 2013)
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        CG2158KG09557
        Nup50KG09557
        (Freibaum et al., 2015, Zhan et al., 2013)
        Name Synonyms
        Secondary FlyBase IDs
          References (3)