Allele Dmel\Frq1^{dsRNA.Scer\UAS}

General Information
Symbol	Dmel\Frq1^{dsRNA.Scer\UAS}	Species	D. melanogaster
Name		FlyBase ID	FBal0217376
Feature type	allele	Associated gene	Dmel\Frq1

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - RNAi
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Romero-Pozuelo et al., 2007) in vitro construct - RNAi (Romero-Pozuelo et al., 2007)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of an inverted repeat consisting of a 5kb genomic fragment containing exons 3 through to the beginning of exon 8 of Frq1 followed by a 400bp cDNA fragment of Frq1 in reverse orientation. (Romero-Pozuelo et al., 2007)
Carried in construct	P{UAS-Frq.RNAi} (Romero-Pozuelo et al., 2007)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In

Detailed Description
	Statement Reference
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Other
Statement Reference Frq1^DN.Scer\UAS, Frq1^{dsRNA.Scer\UAS}, Frq2^DN.Scer\UAS, Scer\GAL4^D42 has type I bouton phenotype (Romero-Pozuelo et al., 2007)
Additional Comments
Genetic Interactions
Statement Reference Larvae co-expressing Frq2^DN.Scer\UAS, Frq1^DN.Scer\UAS and Frq1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^D42 show an increase in the number of type 1s boutons at the larval neuromuscular junction, while the number of type 1b boutons is not significantly affected. The amplitude of the evoked excitatory junctional potential (EJP) at the neuromuscular junction is not significantly different from wild type in larvae expressing Frq1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^D42 or Scer\GAL4^elav-C155. The amplitude and frequency of spontaneous mEJPs is not affected in these flies. Quantal content of type 1b and type 1s boutons is unaffected. (Romero-Pozuelo et al., 2007)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	The P{UAS-Frq.RNAi} construct attenuates the expression of both the Frq1 and Frq2 genes. (Romero-Pozuelo et al., 2007)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Frq1^{dsRNA.Scer\UAS}
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Romero-Pozuelo et al., 2007, Europ. J. Neurosci. 26(9): 2428--2443 Chronic and acute alterations in the functional levels of Frequenins 1 and 2 reveal their roles in synaptic transmission and axon terminal morphology. [FBrf0200597]

Allele Dmel\Frq1dsRNA.Scer\UAS

Allele Dmel\Frq1^{dsRNA.Scer\UAS}