FB2025_04 , released October 2, 2025
Allele: Dmel\Frq1DN.UAS
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General Information
Symbol
Dmel\Frq1DN.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0217377
Feature type
allele
Associated gene
Dmel\Frq1
Associated Insertion(s)
Carried in Construct
P{UAS-Frq1.DN}
Key Links
Transgenic product class
dominant_negative_variant
(Romero-Pozuelo et al., 2007)
inframe_deletion
(Romero-Pozuelo et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Romero-Pozuelo et al., 2007)
inframe_deletion
(Romero-Pozuelo et al., 2007)
Mutagen
in vitro construct
(Romero-Pozuelo et al., 2007)
Progenitor genotype
Carried in construct
P{UAS-Frq1.DN}
Cytology
Description

UAS regulatory sequences drive expression of a dominant negative form of Frq1 which consists of the last 33 amino acids of the open reading frame.

(Romero-Pozuelo et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Frq1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Frq1DN.Scer\UAS results in an increase in the total area of the larval neuromuscular junction compared to wild type.

      The amplitude of the evoked excitatory junctional potential (EJP) at the neuromuscular junction is decreased compared to wild type in larvae expressing Frq1DN.Scer\UAS under the control of Scer\GAL4D42.

      Flies expressing Frq1DN.Scer\UAS under the control of Scer\GAL4elav-C155 show a significant reduction in walking speed and in average distance walked in Buridan's paradigm.

      (Romero-Pozuelo et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Larvae co-expressing Frq2DN.Scer\UAS, Frq1DN.Scer\UAS and Frq1dsRNA.Scer\UAS under the control of Scer\GAL4D42 show an increase in the number of type 1s boutons at the larval neuromuscular junction, while the number of type 1b boutons is not significantly affected.

      (Romero-Pozuelo et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Frq1DN.Scer\UAS
      Frq1DN.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)