A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Allele Dmel\Frq1DN.Scer\UAS

General Information
SymbolDmel\Frq1DN.Scer\UASSpeciesD. melanogaster
NameFlyBase IDFBal0217377
Feature typealleleAssociated geneDmel\Frq1
Allele class
Mutagenin vitro construct - regulatory fusion
hide Recent Updates
Description
What does this section display?
This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
Update Feed
Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
atom feed
FB2013_03
FB2013_02
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
hide Nature of the Allele
Allele class
Mutagen
in vitro construct - regulatory fusion
(Romero-Pozuelo et al., 2007)
Mutations Mapped to the Genome
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Progenitor genotype
Nature of the lesion
Statement
Reference
Scer\UAS regulatory sequences drive expression of a dominant negative form of Frq1 which consists of the last 33 amino acids of the open reading frame.
(Romero-Pozuelo et al., 2007)
Carried in construct
P{UAS-Frq1.DN}
(Romero-Pozuelo et al., 2007)
Cytology
hide Phenotypic Data
hide Phenotypic Class
locomotor behavior defective | adult stage, with Scer\GAL4elav-C155
(Romero-Pozuelo et al., 2007)
neuroanatomy defective | larval stage, with Scer\GAL4D42
(Romero-Pozuelo et al., 2007)
neurophysiology defective | larval stage, with Scer\GAL4D42
(Romero-Pozuelo et al., 2007)
hide Phenotype Manifest In
embryonic/larval neuromuscular junction, with Scer\GAL4D42
(Romero-Pozuelo et al., 2007)
hide Detailed Description
Statement
Reference
Expression of Frq1DN.Scer\UAS results in an increase in the total area of the larval neuromuscular junction compared to wild type. The amplitude of the evoked excitatory junctional potential (EJP) at the neuromuscular junction is decreased compared to wild type in larvae expressing Frq1DN.Scer\UAS under the control of Scer\GAL4D42. Flies expressing Frq1DN.Scer\UAS under the control of Scer\GAL4elav-C155 show a significant reduction in walking speed and in average distance walked in Buridan's paradigm.
(Romero-Pozuelo et al., 2007)
hide External Data
Linkouts
hide Interactions
hide Phenotypic Class
hide Phenotype Manifest In
hideOther
Statement
Reference
Frq1DN.Scer\UAS, Frq1dsRNA.Scer\UAS, Frq2DN.Scer\UAS, Scer\GAL4D42 has type I bouton phenotype
(Romero-Pozuelo et al., 2007)
hide Additional Comments
hide Genetic Interactions
Statement
Reference
Larvae co-expressing Frq2DN.Scer\UAS, Frq1DN.Scer\UAS and Frq1dsRNA.Scer\UAS under the control of Scer\GAL4D42 show an increase in the number of type 1s boutons at the larval neuromuscular junction, while the number of type 1b boutons is not significantly affected.
(Romero-Pozuelo et al., 2007)
hide Xenogenetic Interactions
Statement
Reference
hide Complementation & Rescue Data
Comments
hide Stocks ( 0 )
hide Notes on Origin
Discoverer
hide External Crossreferences & Linkouts
Other Crossreferences
Linkouts
hide Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym
Frq1DN.Scer\UAS
 
Name Synonym
Secondary FlyBase IDs
hide References ( 1 )
Research paper
Romero-Pozuelo et al., 2007, Europ. J. Neurosci. 26(9): 2428--2443
Chronic and acute alterations in the functional levels of Frequenins 1 and 2 reveal their roles in synaptic transmission and axon terminal morphology. [FBrf0200597]