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General Information
Symbol
Dmel\rols5a
Species
D. melanogaster
Name
FlyBase ID
FBal0217432
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of P{EP}EP3330 has deleted from -64 to -1632 upstream of the first exon specific to rols isoform 6 (3rd exon of rols). This includes most of the putative rols6 regulatory region.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Initial determination, budding and elongation of Malpighian tubules during stage 13-14 is normal in rols5a homozygous embryos. However rearrangement of tubule cells to produce elongated, 2 cell wide tubules is delayed (from stage 15 to stage 16-17) and partially disrupted. Tubule migration is defective from stage 15. The anterior tubules follow an erratic path through the body cavity, sometimes doubling back to form loops, and never form the wild-type kink in A2/3. Stellate cell (excretory star cell) integration into the Malpighian tubules appears normal in these embryos.

Unlike most other rols alleles, rols5a mutants do not exhibit fusion of somatic or visceral muscles.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
EP(3)3330*5a
rols5a
Name Synonyms
Secondary FlyBase IDs
    References (1)