FlyBase Allele Report: Dmel\mav[UAS.cGa]

General Information

Symbol

Dmel\mav^UAS.cGa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Gesualdi

FlyBase ID

FBal0217501

Feature type

allele

Associated gene

Dmel\mav

Associated Insertion(s)

Carried in Construct

P{UAS-mav.G}

Also Known As

UAS-MAV

Key Links

Transgenic product class

wild_type

(Gesualdi and Haerry, 2007)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Gesualdi and Haerry, 2007)

Mutagen

in vitro construct

(Gesualdi and Haerry, 2007)

Progenitor genotype

Carried in construct

P{UAS-mav.G}

Cytology

Description

UAS regulatory sequences drive expression of mav coding sequence.

(Gesualdi and Haerry, 2007)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

mav

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

dendritic tree | cell non-autonomous | somatic clone | third instar larval stage, with Scer\GAL4^Act.PU

(Hoyer et al., 2018)

dendritic tree | third instar larval stage, with Scer\GAL4^A58

(Hoyer et al., 2018)

dendritic tree | third instar larval stage, with Scer\GAL4^en-e16E

(Hoyer et al., 2018)

dendritic tree | third instar larval stage, with Scer\GAL4^NP0022

(Hoyer et al., 2018)

larval multidendritic class IV neuron | cell non-autonomous | somatic clone | third instar larval stage, with Scer\GAL4^Act.PU

(Hoyer et al., 2018)

larval multidendritic class IV neuron | third instar larval stage, with Scer\GAL4^A58

(Hoyer et al., 2018)

larval multidendritic class IV neuron | third instar larval stage, with Scer\GAL4^en-e16E

(Hoyer et al., 2018)

larval multidendritic class IV neuron | third instar larval stage, with Scer\GAL4^NP0022

(Hoyer et al., 2018)

Detailed Description

Statement

Reference

The expression of mav^UAS.cGa under the control of Scer\GAL4^A58 leads to larval C4da neurons exhibiting a more complex dendrite tree (i.e. longer dendrites with more branches but less isoneuronal dendritic crossings), as compared to controls. Expression under the control of Scer\GAL4^en-e16E leads to longer dendrites in the anterior dendritic region of larval C4da neurons, but not in the posterior dendritic region or the overall dendrite length, as compared to controls.

Expression of mav^UAS.cGa under the control of Scer\GAL4^NP0022 leads to longer and shorter dendrites in the dorsal and ventral dendritic region, respectively, of larval C4da neurons, but does not affect the overall dendrite length, as compared to controls.

Expression of mav^UAS.cGa under the control of Scer\GAL4^GMR41E11 or Scer\GAL4^19-12 does not significantly affect the dendrite tree morphology of larval C1da or C3da neurons, respectively, as compared to controls.

Upon clonal expression of mav^UAS.cGa under the control of Scer\GAL4^Act.PU, C4da neurons exhibit longer dendrites mainly in regions covering mav^UAS.cGa-expressing epithelial cells.

(Hoyer et al., 2018)

Ubiquitous expression of up to four copies of mav^Scer\UAS.cGa, under the control of Scer\GAL4^da.G32 does not result in any noticeable phenotypes. Expression in the wing, under the control of Scer\GAL4^A9 does not alter size or patterning.

(Gesualdi and Haerry, 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^A58, mav^UAS.cGa has abnormal neuroanatomy | third instar larval stage phenotype, suppressible by Ret^ko

(Hoyer et al., 2018)

Scer\GAL4^A58, mav^UAS.cGa has abnormal size | third instar larval stage phenotype, suppressible by Ret^ko

(Hoyer et al., 2018)

Other

Statement

Reference

Ret^UAS.Tag:V5, Scer\GAL4^GMR41E11, mav^UAS.cGa has abnormal neuroanatomy | third instar larval stage phenotype

(Hoyer et al., 2018)

Ret^UAS.Tag:V5, Scer\GAL4^GMR41E11, mav^UAS.cGa has abnormal size | third instar larval stage phenotype

(Hoyer et al., 2018)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^A58, mav^UAS.cGa has larval multidendritic class IV neuron | third instar larval stage phenotype, suppressible by Ret^ko

(Hoyer et al., 2018)

Scer\GAL4^A58, mav^UAS.cGa has dendritic tree | third instar larval stage phenotype, suppressible by Ret^ko

(Hoyer et al., 2018)

Other

Statement

Reference

Ret^UAS.Tag:V5, Scer\GAL4^GMR41E11, mav^UAS.cGa has larval multidendritic class III neuron | third instar larval stage phenotype

(Hoyer et al., 2018)

Ret^UAS.Tag:V5, Scer\GAL4^GMR41E11, mav^UAS.cGa has larval multidendritic class I neuron | third instar larval stage phenotype

(Hoyer et al., 2018)

Ret^UAS.Tag:V5, Scer\GAL4^GMR41E11, mav^UAS.cGa has dendritic tree | third instar larval stage phenotype

(Hoyer et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

The co-expression of mav^UAS.cGa together with Ret^UAS.Tag:V5, but not Ret^{NTΔ.UAS.Tag:V5} or Ret^{CTΔ.UAS.Tag:V5}, under the control of Scer\GAL4^GMR41E11 leads to a more complex dendritic tree in larval C1da neurons, respectively, as compared to controls. The co-expression of mav^UAS.cGa together with Ret^UAS.Tag:V5 under the control of Scer\GAL4^19-12 also leads to a more complex dendritic tree in larval C3da neurons, as compared to controls.