Allele Dmel\fend^Scer\UAS.cUa

General Information
Symbol	Dmel\fend^Scer\UAS.cUa	Species	D. melanogaster
Name	Saccharomyces cerevisiae UAS construct a of Umemiya	FlyBase ID	FBal0217791
Feature type	allele	Associated gene	Dmel\fend

Allele class
Mutagen
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of the entire fend open reading frame (nucleotides 715-1871 of EST LD02203). (Umemiya et al., 2002)
Carried in construct	P{UAS-fend.U} (Umemiya et al., 2002)
Cytology
Phenotypic Data
Phenotypic Class
	neuroanatomy defective \| third instar larval stage, with Scer\GAL4^how-24B (Umemiya et al., 2002) neuroanatomy defective \| third instar larval stage, with Scer\GAL4^l(3)H94-H94 (Umemiya et al., 2002)
Phenotype Manifest In
	embryonic/larval neuromuscular junction \| ectopic, with Scer\GAL4^how-24B (Umemiya et al., 2002) embryonic/larval neuromuscular junction \| ectopic, with Scer\GAL4^l(3)H94-H94 (Umemiya et al., 2002) intersegmental nerve \| third instar larval stage, with Scer\GAL4^how-24B (Umemiya et al., 2002) motor neuron \| third instar larval stage, with Scer\GAL4^how-24B (Umemiya et al., 2002)
Detailed Description
	Statement Reference Third instar larvae expressing fend^Scer\UAS.cUa under the control of Scer\GAL4^how-24B show defects show defects in the targeting of muscle 12 by motor neurons. The terminal branch of ISNb projects to and form synaptic endings on muscle 12 normally. However, in 44.4% of hemisegments, the nerve ending fail to stabilise on muscle 12 and instead send back collaterals that turn back on to muscle 13 and form a number of ectopic synapses on the muscle. Third instar larvae expressing fend^Scer\UAS.cUa under the control of Scer\GAL4^l(3)H94-H94 have ectopic nerve endings on muscle 13 in 48% of segments. Expression of fend^Scer\UAS.cUa under the control of Scer\GAL4^5053A rarely induces the formation of ectopic nerve endings on muscle 13 in third instar larvae. (Umemiya et al., 2002)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	fend^Scer\UAS.cUa
Name Synonym	Saccharomyces cerevisiae UAS construct a of Umemiya
Secondary FlyBase IDs

References ( 1 )
Research paper	Umemiya et al., 2002, J. Neurobiol. 51(3): 205--214 Forked end: a novel transmembrane protein involved in neuromuscular specificity in Drosophila identified by gain-of-function screening. [FBrf0149069]

Allele Dmel\fendScer\UAS.cUa

Allele Dmel\fend^Scer\UAS.cUa