FB2025_01 , released February 20, 2025
Allele: Dmel\nabR52
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General Information
Symbol
Dmel\nabR52
Species
D. melanogaster
Name
FlyBase ID
FBal0217957
Feature type
allele
Associated gene
Dmel\nab
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Félix et al., 2007)
Mutagen
Delta2-3 transposase
(Félix et al., 2007)
Progenitor genotype
nabEP13
(Félix et al., 2007)
Cytology
Description

Imprecise excision of P{EP}nabEP13 has deleted 2.89kb starting from its insertion site anmd extending 3' into the nab gene. Sequence deleted includes the first exon.

(Félix et al., 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:4,158,106..4,160,996 [-]
Comment:

Estimated endpoints of a 2.89 kb deletion resulting from the imprecise excision of the progenitor insertion (P{EP}nab[EP13]).

(Félix et al., 2007)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The Ap2 neuron of the NB5-6T lineage is mis-specified into a Ap1/Nplp1 neuron in mutant embryos.

      (Ulvklo et al., 2012)

      The number of SE2 neurons is normal in nabSH143/nabR52 mutant animals.

      There are no SELK neurons observed in nabSH143/nabR52 mutant animals.

      (Losada-Pérez et al., 2010)

      No increase in cell death is associated with nabR52 homozygous somatic clones in the wing disc.

      (Félix et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of both nabGD1607 and dveKK115422 under the control of Scer\GAL4hh.PU results in a strong reduction in the size of the posterior compartment of the wing.

      (Perea et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      References (12)