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General Information
Symbol
Dmel\DgO43
Species
D. melanogaster
Name
FlyBase ID
FBal0218112
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

G16085069A

Reported nucleotide change:

G2007A

Amino acid change:

W462term | Dg-PA; W379term | Dg-PB; W644term | Dg-PC; W727term | Dg-PD

Reported amino acid change:

W462term

Comment:

TGG to TGA nonsense mutation in codon W462. Reported coordinates appear to be relative to GB:GH09323.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution: G2007A.

Amino acid replacement: W462term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The Dg[-] progeny of DgO38/DgO86 females mated to DgO43/+ males are viable when grown without competition from heterozygous larvae.

The Dg[-] progeny of DgO43/DgO86 females mated to DgO55/+ males are viable when grown without competition from heterozygous larvae.

DgO86/DgO43 animals show reduced viability under normal culture conditions.

67% of eggs laid by DgO43/DgO86 females mated to wild-type males hatch.

85% of eggs laid by DgO38/DgO86 females mated to DgO43/+ males hatch.

79% of eggs laid by DgO43/DgO86 females mated to DgO55/+ males hatch.

Females carrying homozygous germline clones produce eggs that are normal in shape.

DgO43/DgO86 follicle cells show a defect in the organisation of the actin stress fibres; the fibres are still properly aligned in mutant follicle cells, but they do not align along the dorsal-ventral axis, and they sometimes show a mixed orientation within a single cell.

Under normal food conditions, DgO43 mutant follicle cell clones have normal apical-basal polarity.

Homozygotes show a posterior crossvein phenotype with 100% penetrance. More than 90% of wings show a "detached" phenotype (the crossvein is detached from both L4 and L5). A small fraction of wings with a "gapped" phenotype (the crossvein is detached from either vein L4 or L5, but not both) are seen.

DgO43/Df(2R)ED2457 animals show 63% viability compared to controls.

DgO43/DgO55 mutants are arrested at early stages of oogenesis and show mislocalisation of the oocyte.

DgO86/DgO43 mutants are arrested at early stages of oogenesis and show mislocalisation of the oocyte.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (8)