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General Information
Symbol
Dmel\ykiDbo3
Species
D. melanogaster
Name
Dumbo 3
FlyBase ID
FBal0218165
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    point mutation
    Nucleotide change:
    C24067808T
    Amino acid change:
    P147S | yki-PD; P147S | yki-PF; P147S | yki-PG; P170S | yki-PH
    Reported amino acid change:
    P170S
    Comment:
    The reported position of the mutation with respect to the yki protein differs by 23aa from the site in the annotated protein due to the use of a downstream AUG in the FlyBase annotation, which was based on Drosophila species conservation data. The site of the nucleotide substitution in the mutant was inferred by FlyBase based on the reported amino acid change.
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Amino acid replacement: P170S.
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference
    Heterozygotes show a large wing phenotype. Homozygous clones in developing eye tissue have a growth advantage over wild-type cells.
    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Suppressor of
    Statement
    Reference
    yki[+]/ykiDbo3 is a suppressor of visible phenotype of Scer\GAL4nub-AC-62, hpoUAS.cUa
    Phenotype Manifest In
    Suppressor of
    Statement
    Reference
    yki[+]/ykiDbo3 is a suppressor of wing phenotype of Scer\GAL4nub-AC-62, hpoUAS.cUa
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    The small wing phenotype caused by expression of hpoScer\UAS.cUa under the control of Scer\GAL4nub-AC-62 is strongly suppressed by one copy of ykiDbo3.
    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (4)
    Reported As
    Symbol Synonym
    Name Synonyms
    Dumbo 3
    Secondary FlyBase IDs
      References (1)