FB2025_01 , released February 20, 2025
Allele: Dmel\CycCY5
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General Information
Symbol
Dmel\CycCY5
Species
D. melanogaster
Name
FlyBase ID
FBal0218349
Feature type
allele
Associated gene
Dmel\CycC
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Loncle et al., 2007)

amorphic allele - molecular evidence

(Loncle et al., 2007)
Mutagen
Delta2-3 transposase
(Loncle et al., 2007)
Progenitor genotype
P{EP}CycCGE22979
(Loncle et al., 2007)
Caused by aberration
Df(3R)CycCY5
Cytology
Description

Imprecise excision of P{EP}CycCGE22979, resulting in deletion of the entire P{EP} element plus 1429 and 1304 bp 5' and 3' flanking genomic DNA, respectively, thus removing all CycC protein-coding sequences.

(Loncle et al., 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos derived from homozygous female germline clones are smaller than controls and die as embryos without proper denticle formation.

      Pupariation is delayed by approximately 2-3 days in homozygous animals. This developmental delay is not rescued by feeding with 20-hydroxyecdysone.

      97% of homozygous prepupae fail to evert their anterior spiracles, and the prepupae are partially separated from the pupal case.

      The level of ecdysteroids is significantly lower than normal in homozygous late wandering third instar larvae.

      (Xie et al., 2015)

      Homozygous larvae have a significantly increased triglyceride content compared to controls.

      (Zhao et al., 2012)

      Inclusion of a single Scer\GAL4arm.PS, CycCScer\UAS.cLa recombinant chromosome rescues CycCY5 homozygotes to a limited extent, although emerging adults show some loss of sensory organs and malformed sex combs.

      Generation of CycCY5 clones specifically in the leg (using Scer\GAL4Dll-em212 and Scer\FLP1Scer\UAS.cUa) and in a Minute background results in severely stunted legs. In an other wild type background, these clones result in tarsal segmentation defects in all three paris of adult legs. Male prothoracic (T1) legs exhibit sex combs with slightly elevated teeth number and discontinuities in the tooth alignment, leading to irregularly grouped, fragmented sex combs. Leg size is relatively unaffected, but the most proximal tarsal joint is usually abnormal.

      Generation of large CycCY5 clones specifically in the eye (using Scer\FLP1ey.PB) in a Minute background results in full-sized eyes with mostly normal differentiated ommatidia.

      Heat-induced CycCY5 clones in the adult notum are associated with loss of bristles.

      (Loncle et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT suppressed by
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The phenotypes of Cdk8K185 CycCY5 double mutants are similar to those of the single mutants.

      (Xie et al., 2015)

      The partial rescue of CycCY5 or CycCY5/Df(3R)CycCY8 lethality observed when a single Scer\GAL4arm.PS, CycCScer\UAS.cLa recombinant chromosome is present is not further rescued by inclusion of CG3731Ubi-p63E.PL.

      (Loncle et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      CycCY5 is rescued by CycCEGFP

      (Xie et al., 2015)
      Partially rescued by

      CycCY5 is partially rescued by Scer\GAL4arm.PS/CycCUAS.cLa

      (Loncle et al., 2007)
      Comments

      CycCT:Avic\GFP-EGFP rescues the developmental delay to pupariation, the failure of prepupal anterior spiracle eversion and the prepupal lethality of CycCY5 animals.

      (Xie et al., 2015)

      Inclusion of a single Scer\GAL4arm.PS, CycCScer\UAS.cLa recombinant chromosome rescues CycCY5 homozygotes and CycCY5/Df(3R)CycCY8 animals to a limited extent, although emerging adults show some loss of sensory organs and malformed sex combs. Inclusion of two Scer\GAL4arm.PS, CycCScer\UAS.cLa chromosomes leads to extensive rescue of CycCY5 homozygotes and these adults are morphologically normal.

      (Loncle et al., 2007)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CycCY5
      (Zhao et al., 2012, de Ayala Alonso et al., 2007, Loncle et al., 2007)
      CycCy5
      (Tang et al., 2018)
      cycCY5
      (Kuang et al., 2020, Xie et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)