FB2025_02 , released April 17, 2025
Allele: Dmel\flr5
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General Information
Symbol
Dmel\flr5
Species
D. melanogaster
Name
FlyBase ID
FBal0218376
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Small deletion that removes the sixth exon, resulting in a deletion of 76 amino acids (residues 482 to 558).

    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Homozygous clones in the wing result in abnormal wing hairs, with a range of phenotypes being seen. The most extremely affected cells show multiple blebs and ridges, while less affected cells have hairs that are wider, often bent and occasionally split. Homozygous clones in the wing occasionally produce with multiple wing hairs or a fair of obvious abnormal polarity.

    Homozygous clones in the pupal wing show a dramatic cell-autonomous increase in the level of F-actin compared to wild type, and this increase is seen both prior to and during wing hair morphogenesis.

    Mean clone size in the adult wing is smaller when clones are induced at 3-4 days after egg laying (AEL) compared to 4-5 days AEL, indicating that homozygous cells are lost over time. Almost no clones are recovered in adult wings when they are induced at 2-3 days AEL.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Partially rescued by
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (1)
    Reported As
    Symbol Synonym
    Name Synonyms
    Secondary FlyBase IDs
      References (1)