Allele Dmel\tatl^S096713

General Information
Symbol	Dmel\tatl^S096713	Species	D. melanogaster
Name		FlyBase ID	FBal0218459
Feature type	allele	Associated gene	Dmel\tatl
Also Known As	l(3)S096713

Allele class
Mutagen
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference P{lacW} insertion upstream of the upstream open reading frame (moi) of the dicistronic locus that encodes both moi and tatl. (Raffa et al., 2009) Insertion 35bp downstream of the tatl and moi common transcriptional start. (Komonyi et al., 2005)
Caused by insertion	P{lacW}moi^S096713 (Deak et al., 1997, Raffa et al., 2009, Komonyi et al., 2005)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| recessive (Raffa et al., 2009)
Phenotype Manifest In

Detailed Description
	Statement Reference Flies homozygous for the P{lacW}moi[S096713] insertion die as third instar larvae. (Deak et al., 1997)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments	The P3-P4 early pupal lethality seen in P{lacW}moi[S096713]/Df(3R)d189 animals is completely rescued by P{CaSpeR-DTL} (which carries moi[+t4.6] and tatl[+t4.6]). The P3-P4 early pupal lethality seen in P{lacW}moi[S096713]/Df(3R)d189 animals is not rescued by P{CaSpeR-DTLd[m]} (which carries tatl[dm.t4.6] and moi[dm.t4.6]). The P3-P4 early pupal lethality seen in P{lacW}moi[S096713]/Df(3R)d189 animals is partially rescued by P{CaSpeR-DTLu[m]} (which carries tatl[um.t4.6] and moi[um.t4.6]); animals die as pharate adults or immediately after hatching. The P3-P4 early pupal lethality seen in P{lacW}moi[S096713]/Df(3R)d189 animals is completely rescued by P{CaSpeR-DTLd[m]} and P{CaSpeR-DTLu[m]} together in trans. (Komonyi et al., 2005)
Stocks ( 0 )

Notes on Origin
Discoverer
	Associated with: moi[S096713]. (Raffa et al., 2009, Komonyi et al., 2005) The P{lacW}moi[S096713] insertion maps upstream of a dicistronic locus that encodes moi (upstream ORF) and tatl (downstream ORF). Rescue analysis indicates that the telomere fusion phenotype seen in P{lacW}moi[S096713] mutants is due to an effect on the moi ORF and not on tatl. In contrast, the lethality caused by the insertion is not rescued by a transgene containing either ORF alone, but is rescued by a transgene containing functional copies of both ORFs, indicating that the lethality is due to an effect on both ORFs. (Raffa et al., 2009)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	l(3)S096713 (Raffa et al., 2009, Pankotai et al., 2005) tatl^S096713
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Raffa et al., 2009, Proc. Natl. Acad. Sci. U.S.A. 106(7): 2271--2276 The Drosophila modigliani (moi) gene encodes a HOAP-interacting protein required for telomere protection. [FBrf0206682] Komonyi et al., 2005, J. Biol. Chem. 280(13): 12397--12404 DTL, the Drosophila Homolog of PIMT/Tgs1 Nuclear Receptor Coactivator-interacting Protein/RNA Methyltransferase, Has an Essential Role in Development. [FBrf0184045] Pankotai et al., 2005, Mol. Cell. Biol. 25(18): 8215--8227 The homologous Drosophila transcriptional adaptors ADA2a and ADA2b are both required for normal development but have different functions. [FBrf0188111] Deak et al., 1997, Genetics 147(4): 1697--1722 P-element insertion alleles of essential genes on the third chromosome of Drosophila melanogaster: correlation of physical and cytogenetic maps in chromosomal region 86E-87F. [FBrf0099762]
FlyBase analysis	FlyBase Genome Annotators, 2008, Changes affecting gene model number or type in release 5.13 of the annotated D.melanogaster genome. Changes affecting gene model number or type in release 5.13 of the annotated D.melanogaster genome. [FBrf0205930]

Allele Dmel\tatlS096713

Allele Dmel\tatl^S096713