Allele Dmel\14-3-3ζ^II.Scer\UAS

General Information
Symbol	Dmel\14-3-3ζ^II.Scer\UAS	Species	D. melanogaster
Name		FlyBase ID	FBal0218566
Feature type	allele	Associated gene	Dmel\14-3-3ζ

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Acevedo et al., 2007)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of the 14-3-3ζ II isoform. (Acevedo et al., 2007)
Carried in construct	P{UAS-leo.II} (Acevedo et al., 2007, Messaritou et al., 2009, Tsigkari et al., 2012)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In

Detailed Description
	Statement Reference
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference Scer\GAL4^elav-C155/14-3-3ζ^II.Scer\UAS is a suppressor of partially lethal - majority die \| recessive phenotype of 14-3-3ε^ex4 (Acevedo et al., 2007)
Phenotype Manifest In
NOT Suppressor of
Statement Reference 14-3-3ζ^II.Scer\UAS/Scer\GAL4^αTub84B.PL is a non-suppressor of pole cell phenotype of 14-3-3ε^ex4 (Tsigkari et al., 2012) Scer\GAL4^Act5C.PI/14-3-3ζ^II.Scer\UAS is a non-suppressor of pole cell phenotype of 14-3-3ε^ex4 (Tsigkari et al., 2012) Scer\GAL4^{nos.UTR.T:Hsim\VP16}/14-3-3ζ^II.Scer\UAS is a non-suppressor of pole cell phenotype of 14-3-3ε^ex4 (Tsigkari et al., 2012)
Additional Comments
Genetic Interactions
Statement Reference Expression of 14-3-3ζ[II.Scer\UAS] under the control of either Scer\GAL4[αTub84B.PL], Scer\GAL4[Act5C.PI] or Scer\GAL4[nos.UTR.T:Hsim\VP16] does not rescue the reduction in the number of pole cells per gonad seen in 14-3-3ε[ex4] embryos. (Tsigkari et al., 2012)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescues	14-3-3ζ^II.Scer\UAS/Scer\GAL4^elav.PLu rescues 14-3-3ζ^P1188 (Messaritou et al., 2009) 14-3-3ζ^II.Scer\UAS/Scer\GAL4^elav.PLu rescues 14-3-3ζ^P2335/14-3-3ζ^P1188 (Messaritou et al., 2009)
Comments	Expression of 14-3-3ζ[II.Scer\UAS] under the control of Scer\GAL4[elav.PLu] partially rescues the lethality found in 14-3-3ζ[P1188] homozygotes and 14-3-3ζ[P1188]/14-3-3ζ[P2335] heterozygotes to approximately 15-20% of expected. (Messaritou et al., 2009)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	14-3-3ζ^II.Scer\UAS
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Tsigkari et al., 2012, PLoS ONE 7(5): e36702 14-3-3ε is required for germ cell migration in Drosophila. [FBrf0218503] Messaritou et al., 2009, FEBS Lett. 583(17): 2934--2938 A third functional isoform enriched in mushroom body neurons is encoded by the Drosophila 14-3-3zeta gene. [FBrf0208682] Acevedo et al., 2007, Genetics 177(1): 239--253 In vivo functional specificity and homeostasis of Drosophila 14-3-3 proteins. [FBrf0201747]

Allele Dmel\14-3-3ζII.Scer\UAS

Allele Dmel\14-3-3ζ^II.Scer\UAS