Allele Dmel\cry⁰³

General Information
Symbol	Dmel\cry⁰³	Species	D. melanogaster
Name		FlyBase ID	FBal0218577
Feature type	allele	Associated gene	Dmel\cry

Allele class
Mutagen	recombination, SCEI endonuclease, FLPase, ends-out gene targeting
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ends-out gene targeting (Dolezelova et al., 2007) FLPase (Dolezelova et al., 2007) recombination (Dolezelova et al., 2007) SCEI endonuclease (Dolezelova et al., 2007)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	P{(FRT.cry.ends-out)} (Dolezelova et al., 2007)
Nature of the lesion	Statement Reference Ends-out targeting event at the cry locus, using P{(FRT.cry.ends-out)} as the donor template, resulting in the replacement of the entire cry coding region with a w^+* minigene. (Dolezelova et al., 2007)
Cytology
Phenotypic Data
Phenotypic Class
	locomotor rhythm defective (with Df(3R)Dl-BX12) (Dolezelova et al., 2007)
Phenotype Manifest In

Detailed Description
	Statement Reference Most cry⁰³/Df(3R)Dl-BX12 flies behave rhythmically under constant light conditions at 25^oC, approximately one-third of the mutant flies have one periodic component (approximately 24 hours) and the remainder have two periodic components per individual (approximately 22 and 25 hours). cry⁰³ flies entrained to 12 hour light: 12 hour dark cycles and then exposed to 8 hour delayed light-dark (LD) cycles are able to resynchronise to the new light regime. cry⁰³ flies that are entrained to 12 hour light: 12 hour dark cycles (12:12 LD) and are then shifted to 9:9 or 14:14 LD cycles routinely re-entrain to behave in synchrony with the novel non-24 hour cycles. (Dolezelova et al., 2007)
External Data
Linkouts
Interactions
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Phenotypic Class
Other
Statement Reference cry⁰³, norpA³⁶ has locomotor rhythm defective phenotype (Dolezelova et al., 2007)
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference norpA³⁶ cry⁰³ double mutant flies generally fail to resynchronise to the new light regime when they are entrained to 12 hour light: 12 hour dark cycles and then exposed to 8 hour delayed light-dark (LD) cycles; their daily peaks of locomotion continue to occur at the time of the photic transitions that that were in operation before the 8 hour shift. Some of the double mutant flies are "partially entrained"; six says after the photic shift, daily peaks of locomotion fall between the phases expected for continuing entrainment to the old LD regime versus re-entrainment to the new one. norpA³⁶ cry⁰³ double mutant flies are impaired in their ability to re-entrain with novel non-24 hour light:dark (LD) cycles (compared to single mutant flies) when they are entrained to 12:12 LD and are then shifted to 9:9 or 14:14 LD cycles. (Dolezelova et al., 2007)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	cry⁰ (Dolezelova et al., 2007) cry⁰³ (Dolezelova et al., 2007)
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Dolezelova et al., 2007, Genetics 177(1): 329--345 Rhythm defects caused by newly engineered null mutations in Drosophila's cryptochrome gene. [FBrf0201773]

Allele Dmel\cry03

Allele Dmel\cry⁰³