FB2025_01 , released February 20, 2025
Allele: Dmel\GSd312GSd312
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General Information
Symbol
Dmel\GSd312GSd312
Species
D. melanogaster
Name
FlyBase ID
FBal0218658
Feature type
allele
Associated gene
GSd312
Associated Insertion(s)
P{GSV1}GSd312GSd312
Carried in Construct
Also Known As
GSd312
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{GSV1}GSd312GSd312
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    P{GSV1}
    Regulatory region(s)
    UASt
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Expression of GSd312GSd312 under the control of Scer\GAL4109(2)80 results in defects in the dendrites of dorsal cluster dendritic arborisation (da) neurons in third instar larvae: dendrite morphology is defective in the class III da neurons and dendrite branching is reduced in the class IV da neurons.

        Isolated RP2 neuron clones expressing GSd312GSd312 under the control of Scer\GAL4Act5C.PP (clones generated using the Scer\FLP1eve.RN2 line) show a reduction in dendrite growth and a reduction in the number of dendritic branch points at 25-31 hours after egg laying. The distribution of dendrites in the dendritic field is altered: there is a decrease in the number of dendrites targeted to the anterior, posterior, medial and lateral regions of the dendritic field.

        (Ou et al., 2008)

        Fas2-positive axon bundles in the ventral nerve cord are missing or disrupted in embryos expressing GSd312GSd312 under the control of Scer\GAL4scrt-11-6. In the periphery, the SNa motor neuron is missing or thinned, and the ISNb motor neuron is stalled or misrouted.

        (Minidorff et al., 2007)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        GSd312
        (Ou et al., 2008)
        GSd312GSd312
        Name Synonyms
        Secondary FlyBase IDs
          References (3)