|Feature type||allele||Associated gene||Dmel\gwl|
|Allele class||hypomorphic allele - genetic evidence|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
In addition to the amino acid substitution, gwl[Sr6] has a K689STOP substitution.
Amino acid replacement: K689@.
Amino acid replacement: K97M.
Nucleotide substitution: A?T.
|Phenotype Manifest In|
gwl[Sr6] homozygotes die as pupae (although this is believed to reflect a second lethal on its chromosome). gwl[Sr6] mutants are sterile in both males and females. gwl[Sr3]/gwl[6a] mutants exhibit mitotic defects, leading to an increase in the mitotic index with more cells in anaphase. Mutant neuroblasts show a high frequency of defective chromatin condensation. Some regions of chromatin appear undercondensed and other regions are overcondensed. In some cells the chromosomes are uniformly overcondensed, suggesting a lengthy pre-anaphase delay. gwl[Sr3]/gwl[Sr6] adults eclose (after a delay), with variably rough eyes, eroded wing margins, missing bristles and strongly reduced gonads, though viability is reduced. gwl[Sr6]/Df(3L)gwl[3b] mutants die predominantly in the pupal stage, and the rare escaper adults have rough eyes, ragged wings, cuticle defects, missing bristles, and are sterile. gwl[3a]/gwl[Sr6] mutants produce a gwl[Sr3] phenotype, i.e female fertility is restored. gwl/gwl[Sr6] mutants produce a gwl[Sr3] phenotype, i.e female fertility is restored. gwl[6a]/gwl[Sr6] mutants produce a gwl[Sr3] phenotype, i.e female fertility is restored.
|Phenotype Manifest In|
|Complementation & Rescue Data|
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 2 )|
|Secondary FlyBase IDs|
|References ( 1 )|