Allele Dmel\gwl^6a

General Information
Symbol	Dmel\gwl^6a	Species	D. melanogaster
Name		FlyBase ID	FBal0218853
Feature type	allele	Associated gene	Dmel\gwl

Allele class	loss of function allele
Mutagen	P-element activity
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	loss of function allele (Archambault et al., 2007)
Mutagen	P-element activity (Archambault et al., 2007)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	gwl^EP515 (Archambault et al., 2007)
Nature of the lesion	Statement Reference Imprecise excision of P{EP}gwl[EP515] removes the N-terminal end of gwl and it's 5' upstream region. (Archambault et al., 2007)
Cytology
Phenotypic Data
Phenotypic Class
	eclosion rhythm defective (with gwl^Sr3) (Archambault et al., 2007) female fertile (with gwl^Sr3) (Archambault et al., 2007) female fertile (with gwl^Sr6) (Archambault et al., 2007) fertile (with gwl^Sr6) (Archambault et al., 2007) mitotic cell cycle defective (with Df(3L)gwl^3b) (Archambault et al., 2007) mitotic cell cycle defective (with gwl^Sr3) (Archambault et al., 2007) partially lethal - majority die (Archambault et al., 2007) partially lethal - majority live (with gwl^Sr3) (Archambault et al., 2007) sterile (Archambault et al., 2007) sterile (with gwl^Sr3) (Archambault et al., 2007)
Phenotype Manifest In
	chromatin (with Df(3L)gwl^3b) (Archambault et al., 2007) chromatin (with gwl^Sr3) (Archambault et al., 2007) eye (with gwl^Sr3) (Archambault et al., 2007) gonad (with gwl^Sr3) (Archambault et al., 2007) macrochaeta (with gwl^Sr3) (Archambault et al., 2007) wing margin (with gwl^Sr3) (Archambault et al., 2007)
Detailed Description
	Statement Reference gwl[6a] mutants are sterile in both males and females. gwl[6a]/gwl[Sr3] mutants produce a gwl[Sr3] phenotype, i.e female fertility is restored. gwl[6a]/gwl[Sr6] mutants produce a gwl[Sr3] phenotype, i.e female fertility is restored. A significant proportion of gwl[6a]/Df(3L)gwl[3b] cells exhibit polyploid mitotic figures. They also exhibit significant pre-anaphase delay with hyper-condensed chromosomes. (Archambault et al., 2007)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference gwl[+]/gwl^6a is a suppressor of partially lethal - majority die \| dominant \| maternal effect \| embryonic stage phenotype of mts^XE-2258/mts[+], polo¹¹ (Wang et al., 2011)
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference gwl[6a]/+ partially rescues the viability of embryos from mts[XE-2258]/+, polo[11]/+ mothers. (Wang et al., 2011)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	gwl^6a (Archambault et al., 2007, Wang et al., 2011)
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Wang et al., 2011, PLoS Genet. 7(8): e1002227 PP2A-Twins Is Antagonized by Greatwall and Collaborates with Polo for Cell Cycle Progression and Centrosome Attachment to Nuclei in Drosophila Embryos. [FBrf0214683] Archambault et al., 2007, PLoS Genet. 3(11): e200 Mutations in Drosophila Greatwall/Scant reveal its roles in mitosis and meiosis and interdependence with polo kinase. [FBrf0202769]

Allele Dmel\gwl6a

Allele Dmel\gwl^6a