FlyBase Allele Report: Dmel\Egfr[JF01368]

General Information

Symbol

Dmel\Egfr^JF01368

Species

D. melanogaster

Name

FlyBase ID

FBal0219808

Feature type

allele

Associated gene

Dmel\Egfr

Associated Insertion(s)

Carried in Construct

P{TRiP.JF01368}

Also Known As

Egfr^RNAi, UAS-Egfr^RNAi, UAS-EGFR RNAi, UAS-EGFR-RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009.1.15)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009.1.15)

Mutagen

in vitro construct

(Perkins et al., 2009.1.15)

Progenitor genotype

Carried in construct

P{TRiP.JF01368}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009.1.15)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF01368

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates colorectal cancer

modeled by SH3PX1^HMJ21552

(Zhang et al., 2019)

ameliorates glioblastoma

modeled by Pi3K92E^CAAX.UAS, btl::Egfr^λ.UAS

(Chi et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate, with Scer\GAL4^phtm.PO

(Pan and O'Connor, 2021)

partially lethal, with Scer\GAL4^phtm.PO

(Pan and O'Connor, 2021)

visible | adult stage, with Scer\GAL4^ptc.PU

(Zhe et al., 2020)

Phenotype Manifest In

embryonic/larval tracheal section, with Scer\GAL4^btl.PS

(Ruiz et al., 2012)

tarsal segment, with Scer\GAL4^ptc.PU

(Zhe et al., 2020)

tracheal lumen, with Scer\GAL4^btl.PS

(Ruiz et al., 2012)

Detailed Description

Statement

Reference

Expression of Egfr^JF01368 in the fat body under the control of Scer\GAL4^DcG results in significant hyperglycaemia.

Expression of Egfr^JF01368 in muscle under the control of Scer\GAL4^Mef2.PU results in significant hyperglycaemia.

(Ugrankar et al., 2015)

Downregulation of Egfr in the tracheal system through expression of Egfr^JF01368 under the control of Scer\GAL4^btl.PS results in strong gas-filling defects in the terminal cells.

(Ruiz et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Egfr^JF01368, Scer\GAL4^ptc-559.1 is a suppressor of increased size | third instar larval stage phenotype of Scer\GAL4^ptc-559.1, Toll-7^{C993Y.UAS.Tag:FLAG}

(Ding et al., 2022)

Egfr^JF01368, Scer\GAL4^NP5130 is a suppressor of increased cell number | adult stage phenotype of Scer\GAL4^NP5130, aux^NIG.1107R

(Zhao et al., 2022)

Egfr^JF01368, Scer\GAL4^esg.PU is a suppressor of increased occurrence of cell division | adult stage phenotype of Atg1^GD7149, Scer\GAL4^esg.PU

(Zhang et al., 2019)

Phenotype Manifest In

Suppressor of

Statement

Reference

Egfr^JF01368, Scer\GAL4^ptc-559.1 is a suppressor of anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype of Scer\GAL4^ptc-559.1, Toll-7^{C993Y.UAS.Tag:FLAG}

(Ding et al., 2022)

Egfr^JF01368, Scer\GAL4^NP5130 is a suppressor of adult posterior midgut epithelium phenotype of Scer\GAL4^NP5130, aux^NIG.1107R

(Zhao et al., 2022)

Egfr^JF01368, Scer\GAL4^esg.PU is a suppressor of adult midgut epithelium phenotype of Atg1^GD7149, Scer\GAL4^esg.PU

(Zhang et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

25781

y¹ v¹; P{TRiP.JF01368}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

EGFR^IR

(Balmer et al., 2015)

Egfr^JF01368

Egfr^RNAi

(Zhao et al., 2022)

Egfr^v10

(Zhao et al., 2022)

Name Synonyms

Secondary FlyBase IDs

References (20)

Report Sections

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