Expressing ple^JF01813 under the control of Scer\GAL4^Cg.PA leads to fragmented mitochondria in the third instar larval fat body (as assessed by MitoGFP).

Expression of ple^JF01813 under the control of Scer\GAL4^ple.PF in larvae significantly alters mouth hook contractions in the presence, but not absence, of odors, compared to controls.

Expression of ple^JF01813 under the control of Scer\GAL4^GMR64H06 significantly impairs short-term appetitive olfactory memory following training with fructose, compared to controls.

Flies expressing ple^JF01813 under the control of Scer\GAL4^NP6510 show an accelerated age-dependent decline in locomotor performance in a startle-induced negative geotaxis (SING) assay compared to controls.

Rotenone treatment of flies expressing ple^JF01813 under the control of Scer\GAL4^ple.PF increases the mean life span by 20% with respect to Scer\GAL4^ple.PF controls, indicating rotenone toxicity is partially mediated by dopamine levels. Neuronal expression, under the control of Scer\GAL4^elav.PLu increases mean life span by 27%.

Flies expressing ple^JF01813 under the control of Scer\GAL4^ple.PF that are treated for 6 days with rotenone exhibit an approximate 20% loss of dopaminergic neurons, compared to 50% loss in control flies.

ple^JF01813, Scer\GAL4^Cg.PA is a non-enhancer of mitochondrion | third instar larval stage phenotype of Dhpr^HMC05508, Scer\GAL4^Cg.PA

ple^JF01813, Scer\GAL4^Cg.PA is a non-enhancer of embryonic/larval fat body | third instar larval stage phenotype of Dhpr^HMC05508, Scer\GAL4^Cg.PA

ple^JF01813, Scer\GAL4^Cg.PA is a non-suppressor of mitochondrion | third instar larval stage phenotype of Dhpr^HMC05508, Scer\GAL4^Cg.PA

ple^JF01813, Scer\GAL4^Cg.PA is a non-suppressor of embryonic/larval fat body | third instar larval stage phenotype of Dhpr^HMC05508, Scer\GAL4^Cg.PA