FB2025_01 , released February 20, 2025
Allele: Dmel\baboJF01953
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General Information
Symbol
Dmel\baboJF01953
Species
D. melanogaster
Name
FlyBase ID
FBal0219939
Feature type
allele
Associated gene
Dmel\babo
Associated Insertion(s)
Carried in Construct
P{TRiP.JF01953}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Perkins et al., 2009.1.15)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Perkins et al., 2009.1.15)
Mutagen
in vitro construct
(Perkins et al., 2009.1.15)
Progenitor genotype
Carried in construct
P{TRiP.JF01953}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009.1.15)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-JF01953
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of baboJF01953 in the fat body under the control of Scer\GAL4DcG results in significant hyperglycaemia.

      Expression of baboJF01953 in muscle under the control of Scer\GAL4Mef2.PU results in significant hyperglycaemia.

      (Ugrankar et al., 2015)

      Scer\GAL4da.Switch.PT baboJF01953 adults, fed with RU486 to activate expression, show no significant difference in lifespan compared to controls.

      Scer\GAL4Mhc.PW baboJF01953 adults, but not Scer\GAL4Switch1.106 baboJF01953 adults, show extended lifespan compared to controls.

      Scer\GAL4Mhc.PW-mediated expression of baboJF01953 retards the normal decline in flight activity seen in aging flies, and delays the normal increase in protein aggregates and the normal decrease in lysosomes/autophagic vacuoles within muscle.

      Scer\GAL4Mhc.PW-mediated expression of baboJF01953 does not affect female fecundity.

      (Bai et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      baboJF01953
      Name Synonyms
      Secondary FlyBase IDs
        References (10)