FlyBase Allele Report: Dmel\Arc1[JF01974]

General Information

Symbol

Dmel\Arc1^JF01974

Species

D. melanogaster

Name

FlyBase ID

FBal0219960

Feature type

allele

Associated gene

Dmel\Arc1

Associated Insertion(s)

Carried in Construct

P{TRiP.JF01974}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009.1.15)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009.1.15)

Mutagen

in vitro construct

(Perkins et al., 2009.1.15)

Progenitor genotype

Carried in construct

P{TRiP.JF01974}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009.1.15)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF01974

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates tauopathy

modeled by Hsap\MAPT^R406W.UAS

(Schulz et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Adults expressing Arc1^JF01974 under the control of Scer\GAL4^elav-C155 do not show defects in climbing ability, as compared to controls.

(Xu et al., 2019)

Expression of Arc1^JF01974 under the control of Scer\GAL4^E347 results in no difference in larval floating in a density-based assay for body fat content as compared to controls.

(Mosher et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Arc1^JF01974, Scer\GAL4^elav-C155 is a suppressor | partially of visible | adult stage phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155

(Schulz et al., 2023)

Arc1^JF01974, Scer\GAL4^elav-C155 is a suppressor | partially of decreased rate of adult locomotory behavior phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155

(Schulz et al., 2023)

Arc1^JF01974, Scer\GAL4^elav-C155 is a suppressor | partially of increased cell death | adult stage phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155

(Schulz et al., 2023)

Arc1^JF01974, Scer\GAL4^Toll-6-D42 is a suppressor | partially of short lived phenotype of Scer\GAL4^Toll-6-D42, Zzzz\poly-GR^36.UAS.EGFP

(Xu et al., 2019)

Arc1^JF01974, Scer\GAL4^Toll-6-D42 is a suppressor | partially of abnormal locomotor behavior | adult stage phenotype of Scer\GAL4^Toll-6-D42, Zzzz\poly-GR^36.UAS.EGFP

(Xu et al., 2019)

Phenotype Manifest In

Suppressor of

Statement

Reference

Arc1^JF01974, Scer\GAL4^elav-C155 is a suppressor | partially of eye phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155

(Schulz et al., 2023)

Arc1^JF01974, Scer\GAL4^elav-C155 is a suppressor | partially of adult CNS neuron | decreased number phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155

(Schulz et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

25954

y¹ v¹; P{TRiP.JF01974}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Arc1^JF01974

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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