|Feature type||allele||Associated gene||Dmel\TrpA1|
|Mutagen||recombination, ends-in gene targeting|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
A targeted recombination event at the TrpA1 locus which has generated a tandem array of two mutated copies of TrpA1 (represented by TrpA1[ins.5'] and TrpA1[ins.3']). One copy is deleted for the sixth transmembrane domain and carboxy terminus, whereas the other copy is deleted for the promoter region and start codon and contains a translational stop before the transmembrane domains).
|Caused by aberration|
|Phenotype Manifest In|
TrpA1[ins.5'], TrpA1[ins.3'] flies display a reduced aversion to aristolochic acid compared to wild type. In contrast to wild type, TrpA1[ins.5'], TrpA1[ins.3'] flies have virtually no aristolochic acid-induced action potentials in tip recordings of sensillum s6.
Dp(3;3)TrpA1[ins] flies (which carry TrpA1[ins.5'] and TrpA1[ins.3']) show an altered distribution along a thermal gradient compared to wild-type flies. The mutant flies show increased accumulation in the warmest regions (28-32[o]C) of the gradient, but not in the coolest region (18-22[o]C). Df(3L)ED4415/Dp(3;3)TrpA1[ins] flies show an altered distribution along a thermal gradient compared to wild-type flies. The mutant flies show increased accumulation in the warmest regions (28-32[o]C) of the gradient, but not in the coolest region (18-22[o]C). Anterior cell (AC) neurons in the brains of Dp(3;3)TrpA1[ins] flies do not show warmth-responsive increases in intracellular calcium, in contrast to control AC neurons.
|Phenotype Manifest In|
|Complementation & Rescue Data|
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 2 )|
|Secondary FlyBase IDs|
|References ( 2 )|