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General Information
Symbol
Dmel\vkgNIG.16858R
Species
D. melanogaster
Name
FlyBase ID
FBal0220376
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-vkg.RNAiNIG.16858R-3
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of a 500bp inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expressing vkgNIG.16858R under the control of Scer\GAL4bs.Term does not cause air-filling defects or any obvious trachea branching defect in the trachea terminal cells region.

Embryos expressing vkgNIG.16858R under the control of Scer\GAL4how-24B show abnormal attachment of the segment border muscle (SBM) to adjacent muscles and an abnormal SBM shape.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Simultaneous co-expression of both vkgNIG.16858R and Cg25CGD12784 suppresses the melanotic fat body phenotype caused by expression of shiNIG.18102R under the control of Scer\GAL4r4.

Simultaneous co-expression of both vkgNIG.16858R and Cg25CGD12784 suppresses the melanotic phenotype caused by expression of Tl10b.Scer\UAS under the control of Scer\GAL4r4.

At a permissive temperature (18[o]C) coexpression of vkgG454 and vkgNIG.16858R with Cg25CGD12784 under the control of Scer\GAL4Cg.PA and Scer\GAL80ts.αTub84B knocks down expression of vkg. These flies develop into normal adults, although pupal lethality results when the larvae are transferred to restrictive temperature after completion of embryogenesis. Dissection of these larvae 96 hours after the temperature shift reveals highly aberrant shapes in several organs. Imaginal discs, consisting of highly columnar epithelial cells, appear flattened while the ventral nerve cord portion of the central nervous system is strikingly elongated, reminiscent of embryonic defects in ventral nerve cord condensation. Additionally, the ducts and imaginal rings of the salivary glands are dilated, resulting in an expanded lumen.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
vkgNIG.16858R
Name Synonyms
Secondary FlyBase IDs
    References (6)