Allele Dmel\Ir25a²

General Information
Symbol	Dmel\Ir25a²	Species	D. melanogaster
Name		FlyBase ID	FBal0220383
Feature type	allele	Associated gene	Dmel\Ir25a
Also Known As	IR25a²

Allele class	amorphic allele - molecular evidence, loss of function allele
Mutagen	recombination, gene targeting by homologous recombination
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	amorphic allele - molecular evidence (Abuin et al., 2011) loss of function allele (Benton et al., 2009)
Mutagen	gene targeting by homologous recombination (Benton et al., 2009) recombination (Benton et al., 2009)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	fertile (Abuin et al., 2011) neurophysiology defective (Abuin et al., 2011) viable (Abuin et al., 2011)
Phenotype Manifest In

Detailed Description
	Statement Reference Homozygous Ir25a[2] mutant animals are viable and fertile. Ir25a[2] mutant class 4 (ac4) coeloconic sensilla lack electrophysiological responsiveness to phenylethyl amine, while phenylacetaldehyde responses are unchanged. Ir25a[2] mutant class 3 (ac3) coeloconic sensilla exhibit normal electrophysiological responsiveness to propionic acid. Electrophysiological responses to γ-hexalactone persist in Ir25a[2] mutant class 3 (ac3) coeloconic sensilla. Electrophysiological responses to 1,4-diaminobutane, but not to acetic acid, are abolished in Ir25a[2] mutant class 2 (ac2) coeloconic sensilla. Electrophysiological responses to ammonia are retained in Ir25a[2] mutant class 1 (ac1) coeloconic sensilla. (Abuin et al., 2011)
External Data
Linkouts
Interactions
Phenotypic Class
NOT Suppressor of
Statement Reference Ir25a² is a non-suppressor of fertile phenotype of Ir8a¹ (Abuin et al., 2011) Ir25a² is a non-suppressor of viable phenotype of Ir8a¹ (Abuin et al., 2011)
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference Ir8a[1], Ir25a[2] double mutant animals are viable and fertile. (Abuin et al., 2011)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Partially rescued by	Ir25a² is partially rescued by Scer\GAL4^Ir25a.PA/Ir25a^Scer\UAS.cAa (Abuin et al., 2011)
Comments	Expression of Ir25a[Scer\UAS.cAa] driven by Scer\GAL4[Ir25a.PA] partially rescues the odor-evoked electrophysiological response phenotypes in Ir25a[2] mutant coeloconic sensilla. (Abuin et al., 2011)
Stocks ( 1 )
Bloomington	41737 w^*; Ir25a²/CyO
Notes on Origin
Discoverer

Comments
	Generated by gene targeting at the Ir25a locus. (Benton et al., 2009)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	IR25a² (Silbering et al., 2011, Benton et al., 2009, Abuin et al., 2011) Ir25a²
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Abuin et al., 2011, Neuron 69(1): 44--60 Functional architecture of olfactory ionotropic glutamate receptors. [FBrf0212725] Silbering et al., 2011, J. Neurosci. 31(38): 13357--13375 Complementary Function and Integrated Wiring of the Evolutionarily Distinct Drosophila Olfactory Subsystems. [FBrf0215822] Benton et al., 2009, Cell 136(1): 149--162 Variant ionotropic glutamate receptors as chemosensory receptors in Drosophila. [FBrf0206496]

Allele Dmel\Ir25a2

Allele Dmel\Ir25a²