FB2025_01 , released February 20, 2025
Allele: Dmel\rntod
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General Information
Symbol
Dmel\rntod
Species
D. melanogaster
Name
FlyBase ID
FBal0220424
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description

Amino acid replacement: R565Q.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Nucleotide change:

G7275825A

Amino acid change:

R311Q | rn-PC; R565Q | rn-PE; R546Q | rn-PF; R565Q | rn-PG

Reported amino acid change:

R565Q

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
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Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
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Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

rntod mutants exhibit Or67a-expressing olfactory receptor neuron loss in the trichoid subtype at1 sensilla. The DA1 glomerulus targeted by these receptor neurons in the antennal lobe is missing.

rntod/rnGAL4-5 mutants exhibit Or67a-expressing olfactory receptor neuron loss in the trichoid subtype at1 sensilla. The DA1 glomerulus targeted by these receptor neurons in the antennal lobe is missing.

rntod/rntot mutants exhibit Or67a-expressing olfactory receptor neuron loss in the trichoid subtype at1 and at3 sensilla. The DA1 glomerulus targeted by these receptor neurons in the antennal lobe is missing. There is an increase in the number of ORNs in the at4 sensilla.

rntod/rntot mutants exhibit rn-negative olfactory receptor neuron loss in the coeloconic subtype ac1 and ac4 sensilla. The ac2 sensilla expands into the antennal zones that are normally occupied by these sensilla.

rntod/rntot mutants exhibit rn-negative olfactory receptor neuron loss in the basiconic subtype ab5, ab7 and ab10 sensilla. The ab1 and ab9 sensilla show a slight increase in female mutants but not males.

The rn-positive ai1 sensilla is lost in rntot/rntot mutant flies.

Recordings of thre response of single antennal trichoid sensillae to 11-cis-vanyl-acetate (VA) indicate that tod1 homozygotes lack T1 functional subtype of these sensillae. The overall number of trichoid sensilla on the antenna of these flies is about 30% less than wild-type and the number of large basiconic sensilla is that same as wild-type, suggesting that the missing T1 sensillae have not been transformed into other sensillum types.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

rntod/rntot, amos3/Y double mutant males lack all basiconic and trichoid sensilla.

As in lzg/Y mutants alone,the basiconic sensilla in rntod/rntot, lzg/Df(2L)M36F-S6 double mutants have been converted to trichoid sensilla. The at1 sensilla have been converted to at4 in both trichoid zones.

Xenogenetic Interactions
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Complementation and Rescue Data
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Mutant
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Stocks (0)
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External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (3)