Homozygous Trx-2^GE14911 mutant adults are more sensitive to fungal infection (B. bassiana) than wild type controls. This increase in sensitivity is seen following both natural infection and infection through septic injury. No reduction in survival is seen following wounding or in response to infection with Gram-negative bacteria (Ecc-15). A fall in survival rate is seen in response to the Gram-positive bacteria S. aureus, but not M. luteus. Hemocyte number in Trx-2^GE14911 mutant flies is similar to wild type and hemocyte uptake of B. bassiana fungal spores appears normal. Defects are also seen in the phagocytic uptake of S. aureus but not E. coli. The number of plasmatocytes seen in homozygous Trx-2^GE14911 third instar larvae is similar to wild type. A reduced number of crystal cells is seen and less melanisation occurs following injury compared to wild type.

Trx2^GE14911, Scer\GAL4^B11-98 is a non-suppressor of macrochaeta phenotype of Mical^UAS.s, Scer\GAL4^B11-98