Open Close
General Information
Symbol
Dmel\LmptGE27535
Species
D. melanogaster
Name
FlyBase ID
FBal0220433
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Insertion components
    P{EP}LmptGE27535
    Product class / Tool use(s)
    Encoded product / tool
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Homozygous LmptGE27535 mutant adults are more sensitive to fungal infection (B. bassiana) than wild type controls. This increase in sensitivity is seen following both natural infection and infection through septic injury. No reduction in survival is seen following wounding or in response to infection with Gram-negative bacteria (Ecc-15). A fall in survival rate is seen in response to the Gram-positive bacteria S. aureus, but not M. luteus. The number of hemocytes in LmptGE27535 mutant flies is similar to wild type but these hemocytes are defective in the uptake of B. bassiana fungal spores. Defects are also seen in the phagocytic uptake of S. aureus but not E. coli. The number of plasmatocytes in homozygous LmptGE27535 third instar larvae is similar to wild type, as is the number of crystal cells. As in wild type, strong melanisation occurs in response to injury.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    Xenogenetic Interactions
    Statement
    Reference

    The presence of LmptGE27535 enhances the Hsap\ARQ52.Scer\UAS-Scer\GAL4GMR.PF degenerative eye phenotype.

    The presence of LmptGE27535 enhances the Hsap\ARQ12.Scer\UAS-Scer\GAL4GMR.PF degenerative eye phenotype.

    Complementation and Rescue Data
    Comments

    Over-expressing Lmpt using the UAS sequences in LmptGE27535 under the control of Scer\GAL4hs.PU rescues the sensitivity to fungal infection seen in this line.

    Images (0)
    Mutant
    Wild-type
    Stocks (1)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (1)
    Reported As
    Symbol Synonym
    LmptGE27535
    Name Synonyms
    Secondary FlyBase IDs
      References (3)