Allele Dmel\Lmpt^GE27535

General Information
Symbol	Dmel\Lmpt^GE27535	Species	D. melanogaster
Name		FlyBase ID	FBal0220433
Feature type	allele	Associated gene	Dmel\Lmpt

Map ( GBrowse )	Untitled Document
Allele class
Mutagen
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site 3L:16,858,533..16,858,533 (Levis, 2009.3.18, Nedelsky et al., 2010, Jin et al., 2008)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Caused by insertion	P{EP}Lmpt^GE27535 (Levis, 2009.3.18, Nedelsky et al., 2010, Jin et al., 2008)
Cytology
Phenotypic Data
Phenotypic Class
	immune response defective \| adult stage (Jin et al., 2008)
Phenotype Manifest In
	hemocyte \| adult stage (Jin et al., 2008)
Detailed Description
	Statement Reference Homozygous Lmpt[GE27535] mutant adults are more sensitive to fungal infection (B. bassiana) than wild type controls. This increase in sensitivity is seen following both natural infection and infection through septic injury. No reduction in survival is seen following wounding or in response to infection with Gram-negative bacteria (Ecc-15). A fall in survival rate is seen in response to the Gram-positive bacteria S. aureus, but not M. luteus. The number of hemocytes in Lmpt[GE27535] mutant flies is similar to wild type but these hemocytes are defective in the uptake of B. bassiana fungal spores. Defects are also seen in the phagocytic uptake of S. aureus but not E. coli. The number of plasmatocytes in homozygous Lmpt[GE27535] third instar larvae is similar to wild type, as is the number of crystal cells. As in wild type, strong melanisation occurs in response to injury. (Jin et al., 2008)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhancer of
Statement Reference Lmpt^GE27535, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Hsap\AR^Q12.Scer\UAS, Scer\GAL4^GMR.PF (Nedelsky et al., 2010) Lmpt^GE27535, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Hsap\AR^Q52.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Nedelsky et al., 2010)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference The presence of Lmpt[GE27535] enhances the Hsap\AR[Q52.Scer\UAS]-Scer\GAL4[GMR.PF] degenerative eye phenotype. The presence of Lmpt[GE27535] enhances the Hsap\AR[Q12.Scer\UAS]-Scer\GAL4[GMR.PF] degenerative eye phenotype. (Nedelsky et al., 2010)
Complementation & Rescue Data
Rescued by	Lmpt^GE27535 is rescued by Lmpt^GE27535/Scer\GAL4^hs.PU (Jin et al., 2008, Jin et al., 2008)
Rescues	Lmpt^GE27535/Scer\GAL4^hs.PU rescues Lmpt^GE27535 (Jin et al., 2008, Jin et al., 2008)
Comments	Over-expressing Lmpt using the UAS sequences in Lmpt[GE27535] under the control of Scer\GAL4[hs.PU] rescues the sensitivity to fungal infection seen in this line. (Jin et al., 2008)
Stocks ( 1 )
Bloomington	26888 w^*; P{EP}Lmpt^GE27535
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Lmpt^GE27535
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Nedelsky et al., 2010, Neuron 67(6): 936--952 Native functions of the androgen receptor are essential to pathogenesis in a Drosophila model of spinobulbar muscular atrophy. [FBrf0211903] Jin et al., 2008, PLoS Pathog. 4(10): e1000168 Identification and functional analysis of antifungal immune response genes in Drosophila. [FBrf0206045]
Personal communication to FlyBase	Levis, 2009.3.18, Genomic coordinates of P{EP} insertions in antifungal genes. Genomic coordinates of P{EP} insertions in antifungal genes. [FBrf0207426]

Allele Dmel\LmptGE27535

Allele Dmel\Lmpt^GE27535