Homozygous jumuGE27806 mutant adults are more sensitive to fungal infection (B. bassiana) than wild type controls. This increase in sensitivity is seen following both natural infection and infection through septic injury. No reduction in survival is seen following wounding or in response to infection with Gram-negative bacteria (Ecc-15). A fall in survival rate is seen in response to the Gram-positive bacteria S. aureus, but not M. luteus. An increased number of hemocytes are seen in jumuGE27806 mutants compared to wild type but overall hemocyte uptake of B. bassiana fungal spores is similar to wild type. Defects are also seen in the phagocytic uptake of S. aureus but not E. coli. An increased number of plasmatocytes is seen in homozygous jumuGE27806 third instar larvae. The number of crystal cells is similar to wild type and, as in wild type, strong melanisation occurs in response to injury.
jumuGE27806, Scer\GAL4GMR.PF is an enhancer of visible | adult stage phenotype of Hsap\MAPTUAS.cWa, Scer\GAL4GMR.PF
jumuGE27806, Scer\GAL4GMR.PF is an enhancer of eye phenotype of Hsap\MAPTUAS.cWa, Scer\GAL4GMR.PF
jumuGE27806 is rescued by Scer\GAL4hs.PU, jumuGE27806
Scer\GAL4hs.PU, jumuGE27806 rescues jumuGE27806
Over-expressing jumu using the UAS sequences in jumuGE27806 under the control of Scer\GAL4hs.PU rescues the sensitivity to fungal infection seen in this line.