FB2025_01 , released February 20, 2025
Allele: Dmel\jumuGE27806
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General Information
Symbol
Dmel\jumuGE27806
Species
D. melanogaster
Name
FlyBase ID
FBal0220441
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
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Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    Cytology
    Description
    Allele components
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    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
    Expression Data
    Reporter Expression
    Additional Information
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    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
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    References
    Modifiers Based on Experimental Evidence ( 1 )
    Disease
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    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Homozygous jumuGE27806 mutant adults are more sensitive to fungal infection (B. bassiana) than wild type controls. This increase in sensitivity is seen following both natural infection and infection through septic injury. No reduction in survival is seen following wounding or in response to infection with Gram-negative bacteria (Ecc-15). A fall in survival rate is seen in response to the Gram-positive bacteria S. aureus, but not M. luteus. An increased number of hemocytes are seen in jumuGE27806 mutants compared to wild type but overall hemocyte uptake of B. bassiana fungal spores is similar to wild type. Defects are also seen in the phagocytic uptake of S. aureus but not E. coli. An increased number of plasmatocytes is seen in homozygous jumuGE27806 third instar larvae. The number of crystal cells is similar to wild type and, as in wild type, strong melanisation occurs in response to injury.

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    Xenogenetic Interactions
    Statement
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    Complementation and Rescue Data
    Comments

    Over-expressing jumu using the UAS sequences in jumuGE27806 under the control of Scer\GAL4hs.PU rescues the sensitivity to fungal infection seen in this line.

    Images (0)
    Mutant
    Wild-type
    Stocks (1)
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    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (1)
    Reported As
    Name Synonyms
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      References (5)