Allele Dmel\app^e6

General Information
Symbol	Dmel\app^e6	Species	D. melanogaster
Name		FlyBase ID	FBal0220521
Feature type	allele	Associated gene	Dmel\app

Map ( GBrowse )
Allele class	amorphic allele - genetic evidence
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	amorphic allele - genetic evidence (Matakatsu and Blair, 2008)
Mutagen	ethyl methanesulfonate (Matakatsu and Blair, 2008)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 3L:12,209,561..12,209,561 na_change=C12209561T pr_change=R104 \| app-PH; R104 \| app-PI; R104 \| app-PJ; R104 \| app-PK; R104 \| app-PL; R104 \| app-PM; R104 \| app-PO; R104 \| app-PP; R104@ \| app-PQ reported_pr_change=R104@ comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. (Matakatsu and Blair, 2008)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: R104@. (Matakatsu and Blair, 2008)
Cytology
Phenotypic Data
Phenotypic Class
	partially lethal - majority die \| recessive (Matakatsu and Blair, 2008) planar polarity defective (Matakatsu and Blair, 2008) planar polarity defective (with Df(3L)ED4475) (Matakatsu and Blair, 2008)
Phenotype Manifest In
	adult abdomen (with Df(3L)ED4475) (Matakatsu and Blair, 2008) wing hair (Matakatsu and Blair, 2008) wing hair (with Df(3L)ED4475) (Matakatsu and Blair, 2008)
Detailed Description
	Statement Reference Adult escapers have extensive wing planar cell polarity (PCP) defects, both proximally and in a distal region between the third and fourth wing veins. app[e6]/Df(3L)ED4475 animals have planar cell polarity defects in the wing and also in the abdomen where polarity is disturbed around the anterior-posterior boundary and is extensively reversed in the posterior compartment. Small to moderately size homozygous clones in the wing do not affect PCP, while large clones only affect PCP in the regions of the wing where PCP defects are seen in homozygous flies. There is no tendency to reorient hairs at clone boundaries. (Matakatsu and Blair, 2008)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference app^e6 has planar polarity defective phenotype, suppressible by Scer\GAL4^ap-md544/d^{Scer\UAS.T:SV5\V5,T:Zzzz\His6} (Matakatsu and Blair, 2008)
Suppressor of
Statement Reference app^e6 is a suppressor \| partially of lethal \| pupal stage phenotype of ft⁸/ft^G-rv (Matakatsu and Blair, 2008) app^e6 is a suppressor \| partially of planar polarity defective \| pupal stage phenotype of ft⁸/ft^G-rv (Matakatsu and Blair, 2008)
Phenotype Manifest In
Suppressor of
Statement Reference app^e6 is a suppressor \| partially of abdomen \| pupal stage phenotype of ft⁸/ft^G-rv (Matakatsu and Blair, 2008) app^e6 is a suppressor of eye disc \| pupal stage phenotype of ft⁸/ft^G-rv (Matakatsu and Blair, 2008) app^e6 is a suppressor of wing disc \| pupal stage phenotype of ft⁸/ft^G-rv (Matakatsu and Blair, 2008)
Other
Statement Reference app^e6, ft⁸/ft^G-rv has wing hair phenotype (Matakatsu and Blair, 2008)
Additional Comments
Genetic Interactions
Statement Reference The disc overgrowth phenotypes of ft[8]/ft[G-rv] pupae are suppressed by app[e6] and the abdominal planar cell polarity (PCP) and lethality phenotypes are reduced in the double mutants compared to the ft[8]/ft[G-rv] single mutant. The double mutant adults have PCP defects in proximal portions of the wing, but not in the distal wing. The PCP defects that are seen between distal veins L4 and L5 in app[e6] mutants are rescued on the dorsal surface by expression of d[Scer\UAS.T:SV5\V5,T:Zzzz\His6] under the control of Scer\GAL4[ap-md544]. (Matakatsu and Blair, 2008)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	app¹ (Matakatsu and Blair, 2008)
Rescued by	app^e6 is rescued by Scer\GAL4^Act.PU/app^RA.Scer\UAS (Matakatsu and Blair, 2008)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	app^e6 (Matakatsu and Blair, 2008)
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Matakatsu and Blair, 2008, Curr. Biol. 18(18): 1390--1395 The DHHC palmitoyltransferase approximated regulates Fat signaling and Dachs localization and activity. [FBrf0206015]

Allele Dmel\appe6

Allele Dmel\app^e6