FB2025_01 , released February 20, 2025
Allele: Dmel\Vha100-1JF02059
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General Information
Symbol
Dmel\Vha100-1JF02059
Species
D. melanogaster
Name
FlyBase ID
FBal0220550
Feature type
allele
Associated gene
Dmel\Vha100-1
Associated Insertion(s)
Carried in Construct
P{TRiP.JF02059}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Perkins et al., 2009.3.31)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Perkins et al., 2009.3.31)
Mutagen
in vitro construct
(Perkins et al., 2009.3.31)
Progenitor genotype
Carried in construct
P{TRiP.JF02059}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009.3.31)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-JF02059
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  cancer
      modeled by HPV18\E6UAS.Tag:MYC, Hsap\UBE3AUAS.cRa
      (Collins et al., 2023)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing Vha100-1JF02059 under the control of Scer\GAL4Cg.PU does not affect the levels of Lysotracker staining (marker of acidic lysosomes) in the third instar larval fat body, as compared to controls.

      (Şentürk et al., 2019)

      The expression of Vha100-1JF02059 under the control of Scer\GAL4SPARC-MI00329-GAL4 (and Dicer-2, for a more efficient RNAi) in the larval fat body induces defective secretion, including intracellular matrix material, as shown by the retention of both secr.GFP and Vkg.GFP.

      (Ke et al., 2018)

      Third instar larvae expressing Vha100-1JF02059 (together with UAS-Dicer2 to enhance RNAi efficiency) under the control of Scer\GAL4ppk.1.9 display hyposensitive behavioral response (lengthened latency till response to 46[o]C thermal probe stimulus) in a thermal nociception assay. However, Vha100-1JF02059 RNAi expression does not affect dendrite coverage in the ddaC dorsal multidendritic neurons compared to controls.

      (Honjo et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Vha100-1JF02059
      Name Synonyms
      Secondary FlyBase IDs
        References (7)