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General Information
Symbol
Dmel\Rab7JF02377
Species
D. melanogaster
Name
FlyBase ID
FBal0220741
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Rab7RNAi, UAS-Rab7-RNAi, UAS-Rab7 RNAi
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Animals expressing Rab7JF02377 under the control of Scer\GAL4grh.D4 are viable, no obvious defects in larval dorsal trunk elongation and airway morphology are observed and the larvae are of comparable size to age-matched controls.

Expression of Rab7JF02377 RNAi under the control of Scer\GAL4GMR.PFa does not perturb the structure or appearance of the adult eye compared to controls.

Expression of Rab7JF02377 in secondary cells under the control of Scer\GAL4dsx.KI reduces exosome secretion into the accessory gland lumen compared to controls.

Expression of Rab7JF02377 (co-expressed with Dcr-2Scer\UAS.cDa) in posterior epidermal cells under the control of Scer\GAL4en-e16E partially prevents phagocytic clearance of ddaC neuron dendrite debris following pupal stage dendritic pruning. In contrast, when larval dendrites are injured (severed with an infrared laser) dendritic debris is completely cleared.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhancer of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Expression of Rab7JF02377 RNAi in animals expressing egrScer\UAS.cMa under the control of Scer\GAL4GMR.PFa does not perturb the localization of egr to early endosomes in third instar larval eye disc.

The dot-like small eye phenotype characteristic for flies expressing egrScer\UAS.cMa under the control of Scer\GAL4GMR.PFa is exacerbated further by co-expression of Rab7JF02377 RNAi resulting in a 'no eye' phenotype with necrosis-like tissue present.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Rab7JF02377
Name Synonyms
Secondary FlyBase IDs
    References (8)