FlyBase Allele Report: Dmel\Lrrk[RNAi.UAS.cIa]

General Information

Symbol

Dmel\Lrrk^RNAi.UAS.cIa

Species

D. melanogaster

Name

FlyBase ID

FBal0220791

Feature type

allele

Associated gene

Dmel\Lrrk

Associated Insertion(s)

Carried in Construct

P{UAS-Lrrk.RNAi.I}

Also Known As

UAS-dLRRK RNAi, UAS-Lrrk RNAi

Key Links

Transgenic product class

RNAi_reagent

(Imai et al., 2008)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Imai et al., 2008)

Mutagen

in vitro construct

(Imai et al., 2008)

Progenitor genotype

Carried in construct

P{UAS-Lrrk.RNAi.I}

Cytology

Description

UAS regulatory sequences drive expression of a Lrrk RNAi construct.

(Imai et al., 2008)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Lrrk

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates tauopathy

modeled by Hsap\MAPT^R406W.UAS

(Bardai et al., 2018)

exacerbates Parkinson's disease 1

modeled by Hsap\SNCA^QUAS.cOa

(Sarkar et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

chemical resistant, with Scer\GAL4^da.G32

(Imai et al., 2008)

Phenotype Manifest In

Detailed Description

Statement

Reference

Flies expressing Lrrk^{dsRNA.Scer\UAS.cIa} under the control of Scer\GAL4^da.G32 show significantly higher resistance to hydrogen peroxide compared to control flies.

(Imai et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Lrrk^RNAi.UAS.cIa/Scer\GAL4^nSyb.PP is an enhancer of abnormal locomotor behavior | adult stage phenotype of Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb

(Sarkar et al., 2021)

Lrrk^RNAi.UAS.cIa/Scer\GAL4^nSyb.PP is an enhancer of decreased cell number | adult stage phenotype of Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb

(Sarkar et al., 2021)

Phenotype Manifest In

Enhancer of

Statement

Reference

Lrrk^RNAi.UAS.cIa/Scer\GAL4^nSyb.PP is an enhancer of outer medulla | adult stage phenotype of Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb

(Sarkar et al., 2021)

Lrrk^RNAi.UAS.cIa/Scer\GAL4^nSyb.PP is an enhancer of medulla intrinsic columnar neuron | adult stage | decreased number phenotype of Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb

(Sarkar et al., 2021)

Lrrk^RNAi.UAS.cIa/Scer\GAL4^nSyb.PP is an enhancer of dopaminergic medulla neuron | adult stage | decreased number phenotype of Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb

(Sarkar et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Lrrk^RNAi.UAS.cIa

Lrrk^{dsRNA.Scer\UAS.cIa}

Lrrk^{dsRNA.UAS.cIa}

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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