FB2025_01 , released February 20, 2025
Allele: Dmel\Herc4G5486
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General Information
Symbol
Dmel\Herc4G5486
Species
D. melanogaster
Name
FlyBase ID
FBal0220882
Feature type
allele
Associated gene
Dmel\Herc4
Associated Insertion(s)
P{EP}Herc4G5486
Carried in Construct
Also Known As
P{EP}CG9153G5486
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Kanoh et al., 2015)
Mutagen
P-element activity
(Bellen, 2009.4.8)
Progenitor genotype
Associated Insertion(s)
P{EP}Herc4G5486
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{EP}
Regulatory region(s)
UAS
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      SherpaG5486 mutant flies are viable and fertile and have no external morphological defects.

      SherpaG5486 mutant flies how increased susceptibility to infection with some gram positive bacteria (S. saprophyticus and E.faecalis) compared with controls. Response to infection to gram-negative bacteria (Erwinia carotovora carotovora 15 (Ecc15)) is normal.

      (Kanoh et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Herc4G5486 is a suppressor of visible phenotype of Scer\GAL4GMR.PF, cindrRNAi.PC.PD.UAS

      (Ketosugbo et al., 2017)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Herc4G5486 is a suppressor of eye phenotype of Scer\GAL4GMR.PF, cindrRNAi.PC.PD.UAS

      (Ketosugbo et al., 2017)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Excision of the P-element in P{EP}SherpaG5486 results in flies to express a normal amount of Sherpa mRNA.

      (Kanoh et al., 2015)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      CG9153G5486
      (Kanoh et al., 2015, Bellen, 2009.4.8)
      Herc4G5486
      SherpaG5486
      herc4G5486
      (Jiang et al., 2019)
      sherpa1
      (Kanoh et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)