Allele Dmel\RecQ4^G7470

General Information
Symbol	Dmel\RecQ4^G7470	Species	D. melanogaster
Name		FlyBase ID	FBal0220932
Feature type	allele	Associated gene	Dmel\RecQ4

Map ( GBrowse )	Untitled Document
Allele class
Mutagen	P-element activity
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	P-element activity (Bellen, 2009.4.8)
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site 3L:8,168,992..8,168,992 (Bellen, 2009.4.8, Wu et al., 2008)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference P{EP}RecQ4[G7470] is inserted in the 5' untranslated region of RecQ4, 43 base pairs upstream of the translation initiation codon. (Wu et al., 2008)
Caused by insertion	P{EP}RecQ4^G7470 (Bellen, 2009.4.8, Wu et al., 2008)
Cytology
Phenotypic Data
Phenotypic Class
	cell cycle defective (Wu et al., 2008) female sterile (Wu et al., 2008) partially lethal - majority live (Wu et al., 2008)
Phenotype Manifest In
	egg (Wu et al., 2008) spiracle (Wu et al., 2008)
Detailed Description
	Statement Reference RecQ4[G7470] flies are homozygous viable, albeit with a low viability. While male fertlity is unaffected, females are sterile, due to a defect in oogenesis. RecQ4[G7470] mutant females lay eggs with fragile eggshells and hatch embryos with spiracle defects. No apparent defect is observed in follicle cells during mitotic cycles and endocycles before stage 10B. BrdU incorporation in chorion gene clusters on both the X and third chromosome is greatly reduced in follicle cells of hypomorphic mutants, with incorporation decreased about 5-fold compared to controls. (Wu et al., 2008)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	RecQ4^G7470 is rescued by RecQ4^T:Avic\GFP (Wu et al., 2008)
Comments	RecQ4[T:Avic\GFP] fully rescues the infertility of RecQ4[G7470] females. (Wu et al., 2008)
Stocks ( 1 )
Bloomington	27228 y¹ w^*; P{EP}RecQ4^G7470/TM3, Sb¹ Ser¹
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	RecQ4^G7470 (Bellen, 2009.4.8)
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Wu et al., 2008, Dev. Biol. 323(1): 130--142 Drosophila homologue of the Rothmund-Thomson syndrome gene: essential function in DNA replication during development. [FBrf0209176]
Personal communication to FlyBase	Bellen, 2009.4.8, BDGP_2009_0408.GenExel.xml BDGP_2009_0408.GenExel.xml [FBrf0207636]

Allele Dmel\RecQ4G7470

Allele Dmel\RecQ4^G7470