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General Information
Symbol
Dmel\spdoH7
Species
D. melanogaster
Name
FlyBase ID
FBal0220942
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Mutagen
    Nature of the Allele
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    This allele may be caused by a deficiency associated with the insertion P{lacW}tmodH7 which deletes the spdo gene - possibly extending to the insertion site of P{lacW}Y1444.

    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In

    embryonic peripheral nervous system & glial cell

    peripheral nervous system precursor cluster & neuron | supernumerary

    Detailed Description
    Statement
    Reference

    Shows severe phenotype in trans to Df(3R)tll-g. spdoH7 embryos display an approximate doubling of the number of neurons in the PNS, though the neurons are distributed among the four typical clusters in each segment and the overall morphology of the embryos is not affected. Glial cells associated with these clusters are missing.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Suppressed by
    Statement
    Reference

    spdoH7 has embryonic peripheral nervous system & glial cell | supernumerary phenotype, suppressible | partially by tmodhs.PDL

    Suppressor of
    Statement
    Reference

    spdoH7 is a suppressor of embryonic peripheral nervous system & neuron phenotype of numb1

    spdoH7 is a suppressor of embryonic peripheral nervous system & glial cell | supernumerary phenotype of numb1

    Additional Comments
    Genetic Interactions
    Statement
    Reference

    The phenotype of double mutants with numb1 does not resemble the numb1 phenotype, but the spdo mutant phenotype. tmodhs.PDL partially suppresses the loss of pros expressing glial cells in the embryonic peripheral nervous system of spdoH7 embryos. The phenotype of double mutants with spdoH7 does not resemble the numb1 phenotype, but the spdo mutant phenotype. In the absence of numb two dbd glial cells are seen. In double mutants with spdoH7, the dbd glial cell is missing, as for spdo mutants. spdoH7/spdoH7 largely suppresses the reduction in neuron numbers seen in stage 15 numb1 homozygous embryos.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer

    Associated with: tmodH7.

    Associated with: tmodH7

    Evidence suggests that the "H7" chromosome contains lesions that affect both tmod and spdo (as suggested in FBrf0182569 and FBrf0183486); the P{lacW}tmodH7 insertion maps within the tmod transcription unit (see FBrf0102830) and the "H7" chromosome also fails to complement spdo mutations, suggesting that there is a second lesion that affects spdo. The nature of the lesion(s) is not known, however data from FBrf0183486 suggests that there may be a deletion extending from the site of the progenitor insertion to the P{lacW}tmodH7 insertion in tmod.

    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (1)
    Reported As
    Symbol Synonym
    spdoH7
    Name Synonyms
    Secondary FlyBase IDs
    • FBal0046512
    References (4)