Allele Dmel\mwh^Scer\UAS.cYa

General Information
Symbol	Dmel\mwh^Scer\UAS.cYa	Species	D. melanogaster
Name	Saccharomyces cerevisiae UAS construct a of Yan	FlyBase ID	FBal0220987
Feature type	allele	Associated gene	Dmel\mwh

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Yan et al., 2008)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of mwh. (Yan et al., 2008)
Carried in construct	P{UAS-mwh.Y} (Yan et al., 2009, Yan et al., 2008, Lu et al., 2010, Gault et al., 2012)
Cytology
Phenotypic Data
Phenotypic Class
	planar polarity defective, with Scer\GAL4^ptc-559.1, Scer\GAL4^tub.PU (Yan et al., 2008) visible, with Scer\GAL4^ptc-559.1, Scer\GAL4^tub.PU (Yan et al., 2008)
Phenotype Manifest In
	wing hair, with Scer\GAL4^ptc-559.1, Scer\GAL4^tub.PU (Yan et al., 2008) wing hair \| supernumerary, with Scer\GAL4^ptc-559.1, Scer\GAL4^tub.PU (Yan et al., 2008)
Detailed Description
	Statement Reference Overexpression of mwh[Scer\UAS.cYa] alone under the control of Scer\GAL4[en-e16E] does not result in wing hair abnormalities. (Gault et al., 2012) Expression of mwh[Scer\UAS.cYa] under the control of Scer\GAL4[ptc-559.1] does not result in any change in the actin cytoskeleton of wing discs and does not result in a change in the timing of hair initiation of the appearance of cytoskeleton in pupal wings. Flies expressing mwh[Scer\UAS.cYa] under the control of both Scer\GAL4[ptc-559.1] and Scer\GAL4[tub] have a mutant wing hair phenotype; small wing hairs are occasionally seen, some cells fail to form a hair, multiple wing hairs are seen and regions of slightly altered polarity are seen. These phenotypes are primarily seen in the vicinity of the posterior cross vein and in the proximal part of the anteriormost region of the wing, and although the phenotype is weak, it shows complete penetrance. In 32 hour pupal wings of this genotype, hair initiation is delayed over a substantial part of the ptc expression domain and near the posterior cross vein. (Yan et al., 2008)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement Reference Scer\GAL4^en-e16E/mwh^Scer\UAS.cYa is a suppressor of wing hair \| supernumerary phenotype of Scer\GAL4^en-e16E, gish^GD10588 (Gault et al., 2012)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescues	Scer\GAL4^ap-md544/mwh^Scer\UAS.cYa rescues mwh^unspecified (Yan et al., 2008) Scer\GAL4^en-e16E/mwh^Scer\UAS.cYa rescues mwh^unspecified (Yan et al., 2008)
Partially rescues	Scer\GAL4^Act.PU/mwh^Scer\UAS.cYa partially rescues mwh^unspecified (Yan et al., 2008)
Comments	Expression of mwh[Scer\UAS.cYa] under the control of Scer\GAL4[Act] almost completely rescues the mwh[unspecified] mutant phenotype. Expression of mwh[Scer\UAS.cYa] under the control of Scer\GAL4[ptc-559.1] results in very little rescue of the mwh[unspecified] mutant phenotype and this rescue is restricted to very proximal parts of the ptc expression domain. (Yan et al., 2008)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	CG43772^Scer\UAS.cYa mwh^Scer\UAS.cYa
Name Synonym	Saccharomyces cerevisiae UAS construct a of Yan
Secondary FlyBase IDs

References ( 4 )
Research paper	Gault et al., 2012, J. Cell Biol. 196(5): 605--621 Drosophila CK1-γ, gilgamesh, controls PCP-mediated morphogenesis through regulation of vesicle trafficking. [FBrf0217630] Lu et al., 2010, Genetics 185(2): 549--558 The Drosophila planar polarity proteins inturned and multiple wing hairs interact physically and function together. [FBrf0211207] Yan et al., 2009, Dev. Biol. 333(1): 186--199 Rho1 has multiple functions in Drosophila wing planar polarity. [FBrf0208582] Yan et al., 2008, Genetics 180(1): 219--228 The multiple-wing-hairs gene encodes a novel GBD-FH3 domain-containing protein that functions both prior to and after wing hair initiation. [FBrf0206936]

Allele Dmel\mwhScer\UAS.cYa

Allele Dmel\mwh^Scer\UAS.cYa