FB2025_01 , released February 20, 2025
Allele: Dmel\Bap170Δ65
Open Close
General Information
Symbol
Dmel\Bap170Δ65
Species
D. melanogaster
Name
FlyBase ID
FBal0221010
Feature type
allele
Associated gene
Dmel\Bap170
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Carrera et al., 2008)
Progenitor genotype
P{EPgy2}Trap1EY10238
(Carrera et al., 2008)
Cytology
Description

956bp deletion that extends from upstream of the Bap170 transcriptional start site into the second exon, moving the first 213 amino acid residues. This deletion leaves Trap1 and the intergenic region between Trap1 and Bap170 intact, and presumably resulted from a transposition of the P{EPgy2}Trap1EY10238 insertion into the 5'UTR of Bap170, followed by an imprecise excision.

(Carrera et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes have reduced adult viability (30 to 33% at 25[o}C), but the adult survivors have no morphological defects except for variable ectopic wing vein material.

      (Carrera et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      Bap170Δ65, Su(var)3-3[+]/Su(var)3-3ΔN has visible | dominant phenotype

      (Curtis et al., 2011)

      Bap170Δ65, polybromoΔ86 has lethal | pupal stage phenotype

      (Carrera et al., 2008)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Bap170Δ65 polybromoΔ86 double mutants show fully penetrant pupal lethality, which can be rescued by ubiquitous expression of either polybromoScer\UAS.cCa or Bap170Scer\UAS.cCa.

      Bap170Δ65 polybromoΔ86 double mutant larvae show overproduction of crystal cells.

      Bap170Δ65 polybromoΔ86 double mutants show defects at the pupal stage beginning approximately 12 hours after puparium formation; the mutants fail to fully evert their legs and sometimes have melanotic patches.

      Embryos laid by Bap170Δ65 females containing polybromoΔ86 homozygous germ line clones die before the third larval instar. Cuticles secreted by the embryos that fail to hatch show dorsalisation (ventral denticle belts are reduced), especially in the anterior region.

      Bap170Δ65 females with osa308 polybromoΔ86 germ lines clones are able to differentiate oocytes.

      (Carrera et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Bap170Δ65
      (Curtis et al., 2011, Di Stefano et al., 2011)
      bap170Δ65
      (Hong and Choi, 2016, Rendina et al., 2010, Carrera et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)