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General Information
Symbol
Dmel\Scgδ840
Species
D. melanogaster
Name
FlyBase ID
FBal0221042
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Sgcd840
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of the P{SUPor-P}ScgδKG05430 insertion, resulting in a deletion of approximately 6.5kb which extends from the original insertion site upstream of Scgδ exon 1 through exon 4.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
is ameliorated by Med13
is ameliorated by Mad12
is ameliorated by Med17
is ameliorated by Med15
model of  cardiomyopathy
is ameliorated by Med13
is NOT ameliorated by Mad12
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Mutant adults do not spend as much time in flight as wild-type controls when housed in a 20cm[3] box to permit ad libitum flight, but the amount of flight is sufficient to induce injury in the indirect flight muscles; muscle disruption is occasionally apparent in non-exercised mutant flies, but muscle tears in the indirect flight muscles are larger and more frequently seen in the exercised flies housed in the 20cm[3] box. Very rarely, infiltration of non-muscle cells that resemble hemocytes into the indirect flight muscles is seen in the exercised flies.

Mutant flies show age-dependent severe loss of climbing ability in a negative geotaxis assay.

The end-systolic and end-diastolic diameters of the heart as measured by optical coherence tomography are increased in the mutant adults compared to controls (indicating a dilated heart tube).

Scgδ840 mutants present a decreased adult lifespan, as compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Phenotype Manifest In
Suppressed by
Statement
Reference

Scgδ840 has adult heart phenotype, suppressible by SmoxG0348/Smox[+]

Scgδ840 has adult heart phenotype, suppressible by Med13/Med[+]

NOT suppressed by
Statement
Reference

Scgδ840 has adult heart phenotype, non-suppressible by Mad12/Mad[+]

Additional Comments
Genetic Interactions
Statement
Reference

The severe loss of climbing ability in a negative geotaxis assay which is seen in Scgδ840 mutants is suppressed if the flies are also carrying either SmoxG0348/+, Mad12/+, Med13/+, Med17/+ or Med15/+.

The dilated heart tube seen in Scgδ840 adults (detected as increased end-systolic and end-diastolic diameters as measured by optical coherence tomography) is rescued if the flies are carrying either SmoxG0348/+ or Med13/+, but is not rescued if the flies are carrying Mad12/+.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (4)